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Comparison of Therapeutic Approaches to Addicted Patients with Central Sleep Apnea

BACKGROUND: Nowadays, the most practical approaches used to treat sleep apnea, are Continuous Positive Airway Pressure (CPAP), Bi-level Positive Airway Pressure therapy (BPAP), supplemental O(2), servoventilation and/or a combination of these approaches simultaneously. However, each leads to differe...

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Autores principales: Schoebel, Christoph, Ghaderi, Amir, Amra, Babak, Soltaninejad, Forogh, Penzel, Thomas, Fietze, Ingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Research Institute of Tuberculosis and Lung Disease 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428378/
https://www.ncbi.nlm.nih.gov/pubmed/30915131
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author Schoebel, Christoph
Ghaderi, Amir
Amra, Babak
Soltaninejad, Forogh
Penzel, Thomas
Fietze, Ingo
author_facet Schoebel, Christoph
Ghaderi, Amir
Amra, Babak
Soltaninejad, Forogh
Penzel, Thomas
Fietze, Ingo
author_sort Schoebel, Christoph
collection PubMed
description BACKGROUND: Nowadays, the most practical approaches used to treat sleep apnea, are Continuous Positive Airway Pressure (CPAP), Bi-level Positive Airway Pressure therapy (BPAP), supplemental O(2), servoventilation and/or a combination of these approaches simultaneously. However, each leads to different consequences in opioid related Central Sleep Apnea (CSA) patients. Given the high prevalence of CSA and frequently use of opioids worldwide, it seems that evaluation of the condition in these patients is required to determine their responsiveness to the above mentioned treatments and to choose the most appropriate therapy. MATERIALS AND METHODS: This longitudinal cross-sectional study included 41 opioid related CSA patients who underwent a step-by-step protocol (including CPAP, CPAP + O(2) and BPAP) in which if the patient was nonresponsive to a treatment, the next therapy was applied. If the patient was nonresponsive to all of these approaches, only oxygen was administered. Finally, the collected data were analyzed with SPSS software (ver. 22). RESULTS: Among 41 participants, the responsiveness to CPAP, CPAP+O(2) and BPAP were 41.5%, 14.6% and 39%, respectively versus 4.9% nonresponsive patients to all above mentioned therapies. In patients with CSA and opium addiction, the CPAP and BPAP were the most effective treatments. In this group of patients, better response in the presence of higher Apnea–Hypopnea Index (AHI) was observed to BPAP, whereas better response in patients with lower AHI was to CPAP+O(2) CONCLUSION: Accordingly, CPAP and BPAP are successful approaches to treat opioid related CSA patients in various medical conditions including long-run addiction course, concurrent smoking and addiction but it appears that further studies are essential.
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spelling pubmed-64283782019-03-26 Comparison of Therapeutic Approaches to Addicted Patients with Central Sleep Apnea Schoebel, Christoph Ghaderi, Amir Amra, Babak Soltaninejad, Forogh Penzel, Thomas Fietze, Ingo Tanaffos Original Article BACKGROUND: Nowadays, the most practical approaches used to treat sleep apnea, are Continuous Positive Airway Pressure (CPAP), Bi-level Positive Airway Pressure therapy (BPAP), supplemental O(2), servoventilation and/or a combination of these approaches simultaneously. However, each leads to different consequences in opioid related Central Sleep Apnea (CSA) patients. Given the high prevalence of CSA and frequently use of opioids worldwide, it seems that evaluation of the condition in these patients is required to determine their responsiveness to the above mentioned treatments and to choose the most appropriate therapy. MATERIALS AND METHODS: This longitudinal cross-sectional study included 41 opioid related CSA patients who underwent a step-by-step protocol (including CPAP, CPAP + O(2) and BPAP) in which if the patient was nonresponsive to a treatment, the next therapy was applied. If the patient was nonresponsive to all of these approaches, only oxygen was administered. Finally, the collected data were analyzed with SPSS software (ver. 22). RESULTS: Among 41 participants, the responsiveness to CPAP, CPAP+O(2) and BPAP were 41.5%, 14.6% and 39%, respectively versus 4.9% nonresponsive patients to all above mentioned therapies. In patients with CSA and opium addiction, the CPAP and BPAP were the most effective treatments. In this group of patients, better response in the presence of higher Apnea–Hypopnea Index (AHI) was observed to BPAP, whereas better response in patients with lower AHI was to CPAP+O(2) CONCLUSION: Accordingly, CPAP and BPAP are successful approaches to treat opioid related CSA patients in various medical conditions including long-run addiction course, concurrent smoking and addiction but it appears that further studies are essential. National Research Institute of Tuberculosis and Lung Disease 2018-03 /pmc/articles/PMC6428378/ /pubmed/30915131 Text en Copyright© 2018 National Research Institute of Tuberculosis and Lung Disease http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Schoebel, Christoph
Ghaderi, Amir
Amra, Babak
Soltaninejad, Forogh
Penzel, Thomas
Fietze, Ingo
Comparison of Therapeutic Approaches to Addicted Patients with Central Sleep Apnea
title Comparison of Therapeutic Approaches to Addicted Patients with Central Sleep Apnea
title_full Comparison of Therapeutic Approaches to Addicted Patients with Central Sleep Apnea
title_fullStr Comparison of Therapeutic Approaches to Addicted Patients with Central Sleep Apnea
title_full_unstemmed Comparison of Therapeutic Approaches to Addicted Patients with Central Sleep Apnea
title_short Comparison of Therapeutic Approaches to Addicted Patients with Central Sleep Apnea
title_sort comparison of therapeutic approaches to addicted patients with central sleep apnea
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428378/
https://www.ncbi.nlm.nih.gov/pubmed/30915131
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