Analysis of Polymorphism and Expression Profile of ASIC1 and IL-6 Genes in Patients with Gastric Cancer

ABSTRACT: Gastric cancer is one of the most common upper gastrointestinal malignancies. Some Iranian provinces, such as in the northern and northwestern areas, are at a high risk, whereas the central and western provinces are at a medium and the southern regions at low risk. This study was carried o...

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Detalles Bibliográficos
Autores principales: Heydari-Mehrabadi, Abdulkuddous, Tamandani, Dor Mohammad Kordi, Baranzehi, Taybeh, Hemati, Simin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428554/
https://www.ncbi.nlm.nih.gov/pubmed/30583668
http://dx.doi.org/10.31557/APJCP.2018.19.12.3451
Descripción
Sumario:ABSTRACT: Gastric cancer is one of the most common upper gastrointestinal malignancies. Some Iranian provinces, such as in the northern and northwestern areas, are at a high risk, whereas the central and western provinces are at a medium and the southern regions at low risk. This study was carried out to estimate the impact of the expression patterns of ASIC1 and IL-6 genes and the IL-6rs-174 and ASIC1rs 75624685 polymorphisms in the pathogenesis of gastric cancer. MATERIALS AND METHODS: Tetra-ARMS PCR was employed to analyze the polymorphism status of the ASIC1 and IL-6 genes with 85 paraffin-embedded tissue blocks from cases and 117 normal blood samples as controls. We also investigated mRNA expression levels of these genes in 12 cases and controls using real-time PCR. RESULTS: Our results showed a significant association between expression of ASIC1 and elevated risk of gastric cancer (p<0.001).

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