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Inhibition increases response variability and reduces stimulus discrimination in random networks of cortical neurons
Much of what is known about the contribution of inhibition to stimulus discrimination is due to extensively studied sensory systems, which are highly structured neural circuits. The effect of inhibition on stimulus representation in less structured networks is not as clear. Here we exercise a biosyn...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428807/ https://www.ncbi.nlm.nih.gov/pubmed/30899035 http://dx.doi.org/10.1038/s41598-019-41220-2 |
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author | Haroush, Netta Marom, Shimon |
author_facet | Haroush, Netta Marom, Shimon |
author_sort | Haroush, Netta |
collection | PubMed |
description | Much of what is known about the contribution of inhibition to stimulus discrimination is due to extensively studied sensory systems, which are highly structured neural circuits. The effect of inhibition on stimulus representation in less structured networks is not as clear. Here we exercise a biosynthetic approach in order to study the impacts of inhibition on stimulus representation in non-specialized network anatomy. Combining pharmacological manipulation, multisite electrical stimulation and recording from ex-vivo randomly rewired networks of cortical neurons, we quantified the effects of inhibition on response variability and stimulus discrimination at the population and single unit levels. We find that blocking inhibition quenches variability of responses evoked by repeated stimuli and enhances discrimination between stimuli that invade the network from different spatial loci. Enhanced stimulus discrimination is reserved for representation schemes that are based on temporal relation between spikes emitted in groups of neurons. Our data indicate that – under intact inhibition – the response to a given stimulus is a noisy version of the response evoked in the absence of inhibition. Spatial analysis suggests that the dispersion effect of inhibition is due to disruption of an otherwise coherent, wave-like propagation of activity. |
format | Online Article Text |
id | pubmed-6428807 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-64288072019-03-28 Inhibition increases response variability and reduces stimulus discrimination in random networks of cortical neurons Haroush, Netta Marom, Shimon Sci Rep Article Much of what is known about the contribution of inhibition to stimulus discrimination is due to extensively studied sensory systems, which are highly structured neural circuits. The effect of inhibition on stimulus representation in less structured networks is not as clear. Here we exercise a biosynthetic approach in order to study the impacts of inhibition on stimulus representation in non-specialized network anatomy. Combining pharmacological manipulation, multisite electrical stimulation and recording from ex-vivo randomly rewired networks of cortical neurons, we quantified the effects of inhibition on response variability and stimulus discrimination at the population and single unit levels. We find that blocking inhibition quenches variability of responses evoked by repeated stimuli and enhances discrimination between stimuli that invade the network from different spatial loci. Enhanced stimulus discrimination is reserved for representation schemes that are based on temporal relation between spikes emitted in groups of neurons. Our data indicate that – under intact inhibition – the response to a given stimulus is a noisy version of the response evoked in the absence of inhibition. Spatial analysis suggests that the dispersion effect of inhibition is due to disruption of an otherwise coherent, wave-like propagation of activity. Nature Publishing Group UK 2019-03-21 /pmc/articles/PMC6428807/ /pubmed/30899035 http://dx.doi.org/10.1038/s41598-019-41220-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Haroush, Netta Marom, Shimon Inhibition increases response variability and reduces stimulus discrimination in random networks of cortical neurons |
title | Inhibition increases response variability and reduces stimulus discrimination in random networks of cortical neurons |
title_full | Inhibition increases response variability and reduces stimulus discrimination in random networks of cortical neurons |
title_fullStr | Inhibition increases response variability and reduces stimulus discrimination in random networks of cortical neurons |
title_full_unstemmed | Inhibition increases response variability and reduces stimulus discrimination in random networks of cortical neurons |
title_short | Inhibition increases response variability and reduces stimulus discrimination in random networks of cortical neurons |
title_sort | inhibition increases response variability and reduces stimulus discrimination in random networks of cortical neurons |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428807/ https://www.ncbi.nlm.nih.gov/pubmed/30899035 http://dx.doi.org/10.1038/s41598-019-41220-2 |
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