KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner

Deregulation of KRAS4b signaling pathway has been implicated in 30% of all cancers. Membrane localization of KRAS4b is an essential step for the initiation of the downstream signaling cascades that guide various cellular mechanisms. KRAS4b plasma membrane (PM) binding is mediated by the insertion of...

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Detalles Bibliográficos
Autores principales: Agamasu, Constance, Ghirlando, Rodolfo, Taylor, Troy, Messing, Simon, Tran, Timothy H., Bindu, Lakshman, Tonelli, Marco, Nissley, Dwight V., McCormick, Frank, Stephen, Andrew G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428923/
https://www.ncbi.nlm.nih.gov/pubmed/30846362
http://dx.doi.org/10.1016/j.bpj.2019.02.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428923/
https://www.ncbi.nlm.nih.gov/pubmed/30846362
http://dx.doi.org/10.1016/j.bpj.2019.02.004

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