Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations

Papillary thyroid cancer (PTC) is the most prevalent form of malignancy among all cancers of the thyroid. It is also one of the few cancers with a rapidly increasing incidence. PTC is usually contained within the thyroid gland and generally biologically indolent. Prognosis of the cancer is excellent...

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Autores principales: Abdullah, Mardiaty Iryani, Junit, Sarni Mat, Ng, Khoon Leong, Jayapalan, Jaime Jacqueline, Karikalan, Barani, Hashim, Onn Haji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428975/
https://www.ncbi.nlm.nih.gov/pubmed/30911279
http://dx.doi.org/10.7150/ijms.29935
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author Abdullah, Mardiaty Iryani
Junit, Sarni Mat
Ng, Khoon Leong
Jayapalan, Jaime Jacqueline
Karikalan, Barani
Hashim, Onn Haji
author_facet Abdullah, Mardiaty Iryani
Junit, Sarni Mat
Ng, Khoon Leong
Jayapalan, Jaime Jacqueline
Karikalan, Barani
Hashim, Onn Haji
author_sort Abdullah, Mardiaty Iryani
collection PubMed
description Papillary thyroid cancer (PTC) is the most prevalent form of malignancy among all cancers of the thyroid. It is also one of the few cancers with a rapidly increasing incidence. PTC is usually contained within the thyroid gland and generally biologically indolent. Prognosis of the cancer is excellent, with less than 2% mortality at 5 years. However, more than 25% of patients with PTC developed a recurrence during a long term follow-up. The present article provides an updated condensed overview of PTC, which focuses mainly on the molecular alterations involved and recent biomarker investigations.
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spelling pubmed-64289752019-03-25 Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations Abdullah, Mardiaty Iryani Junit, Sarni Mat Ng, Khoon Leong Jayapalan, Jaime Jacqueline Karikalan, Barani Hashim, Onn Haji Int J Med Sci Review Papillary thyroid cancer (PTC) is the most prevalent form of malignancy among all cancers of the thyroid. It is also one of the few cancers with a rapidly increasing incidence. PTC is usually contained within the thyroid gland and generally biologically indolent. Prognosis of the cancer is excellent, with less than 2% mortality at 5 years. However, more than 25% of patients with PTC developed a recurrence during a long term follow-up. The present article provides an updated condensed overview of PTC, which focuses mainly on the molecular alterations involved and recent biomarker investigations. Ivyspring International Publisher 2019-02-28 /pmc/articles/PMC6428975/ /pubmed/30911279 http://dx.doi.org/10.7150/ijms.29935 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Abdullah, Mardiaty Iryani
Junit, Sarni Mat
Ng, Khoon Leong
Jayapalan, Jaime Jacqueline
Karikalan, Barani
Hashim, Onn Haji
Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations
title Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations
title_full Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations
title_fullStr Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations
title_full_unstemmed Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations
title_short Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations
title_sort papillary thyroid cancer: genetic alterations and molecular biomarker investigations
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428975/
https://www.ncbi.nlm.nih.gov/pubmed/30911279
http://dx.doi.org/10.7150/ijms.29935
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