Cargando…

Glycolytic Enzyme PKM2 Mediates Autophagic Activation to Promote Cell Survival in NPM1-Mutated Leukemia

Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM1) has been defined as a distinct leukemia entity in the 2016 updated WHO classification of myeloid neoplasm. Our previous report showed that autophagic activity was elevated in NPM1-mutated AML, but the underlying molecular mechanisms rema...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Lu, Yang, Liyuan, Yang, Zailin, Tang, Yuting, Tao, Yao, Zhan, Qian, Lei, Li, Jing, Yipei, Jiang, Xueke, Jin, Hongjun, Zou, Qin, Xian, Jingrong, Zhang, Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429014/ https://www.ncbi.nlm.nih.gov/pubmed/30906218 http://dx.doi.org/10.7150/ijbs.30290

Ejemplares similares

INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia
por: Jin, Hongjun, et al.
Publicado: (2018)

Up-regulation of EMT-related gene VCAN by NPM1 mutant-driven TGF-β/cPML signalling promotes leukemia cell invasion
por: Yang, Liyuan, et al.
Publicado: (2019)

NPM1 Mutant Mediated PML Delocalization and Stabilization Enhances Autophagy and Cell Survival in Leukemic Cells
por: Zou, Qin, et al.
Publicado: (2017)

Mutant NPM1-regulated lncRNA HOTAIRM1 promotes leukemia cell autophagy and proliferation by targeting EGR1 and ULK3
por: Jing, Yipei, et al.
Publicado: (2021)

Mutant NPM1-Regulated FTO-Mediated m(6)A Demethylation Promotes Leukemic Cell Survival via PDGFRB/ERK Signaling Axis
por: Xiao, Qiaoling, et al.
Publicado: (2022)

The human nucleophosmin 1 mutation A inhibits myeloid differentiation of leukemia cells by modulating miR-10b
por: Zou, Qin, et al.
Publicado: (2016)

Cytoplasmic Expression of TP53INP2 Modulated by Demethylase FTO and Mutant NPM1 Promotes Autophagy in Leukemia Cells
por: Huang, Junpeng, et al.
Publicado: (2023)

Exploration of Serum Exosomal LncRNA TBILA and AGAP2-AS1 as Promising Biomarkers for Diagnosis of Non-Small Cell Lung Cancer
por: Tao, Yao, et al.
Publicado: (2020)

Tumour‐derived small extracellular vesicles suppress CD8+ T cell immune function by inhibiting SLC6A8‐mediated creatine import in NPM1‐mutated acute myeloid leukaemia
por: Peng, Meixi, et al.
Publicado: (2021)

HMGCR inhibition stabilizes the glycolytic enzyme PKM2 to support the growth of renal cell carcinoma
por: Huang, Jiajun, et al.
Publicado: (2021)

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease
por: Shirai, Tsuyoshi, et al.
Publicado: (2016)

Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development
por: Gao, Lixia, et al.
Publicado: (2023)

PKM2: A Potential Regulator of Rheumatoid Arthritis via Glycolytic and Non-Glycolytic Pathways
por: Xu, Danyi, et al.
Publicado: (2019)

Glycolytic enzyme PKM2 regulates cell senescence but not inflammation in the process of osteoarthritis: PKM2 regulates chondrocyte senescence via p16 (INK4a) transcription
por: Liu, Bo, et al.
Publicado: (2023)

Nucleophosmin Mutations Induce Chemosensitivity in THP-1 Leukemia Cells by Suppressing NF-κB Activity and Regulating Bax/Bcl-2 Expression
por: Zhang, Shuaishuai, et al.
Publicado: (2016)

Moonlight functions of glycolytic enzymes in cancer
por: Shegay, Petr V., et al.
Publicado: (2023)

Acute Promyelocytic Leukemia or Acute Myeloid Leukemia with Mutated NPM1?
por: Cloobs-Venezia, Maximiliano, et al.
Publicado: (2022)

Iridin Prevented Against Lipopolysaccharide-Induced Inflammatory Responses of Macrophages via Inactivation of PKM2-Mediated Glycolytic Pathways
por: Ying, Zhen-Hua, et al.
Publicado: (2021)

How does the NPM1 mutant induce leukemia?
por: Sportoletti, Paolo
Publicado: (2011)

Nucleophosmin1 (NPM1) abnormality in hematologic malignancies, and therapeutic targeting of mutant NPM1 in acute myeloid leukemia
por: Chen, Yingyu, et al.
Publicado: (2020)

JOSD2 regulates PKM2 nuclear translocation and reduces acute myeloid leukemia progression
por: Lei, Hu, et al.
Publicado: (2022)

Trichostatin a Protects Dendritic Cells Against Oxygen-Glucose Deprivation via the SRSF3/PKM2/Glycolytic Pathway
por: Jiang, Hongyun, et al.
Publicado: (2018)

Elevated HOX gene expression in acute myeloid leukemia is associated with NPM1 mutations and poor survival
por: Nagy, Ádám, et al.
Publicado: (2019)

Interactions between glycolytic enzymes and components of the cytomatrix
por: Masters, C.
Publicado: (1984)

The glycolytic enzyme phosphofructokinase-1 assembles into filaments
por: Webb, Bradley A., et al.
Publicado: (2017)

The frequency of NPM1 mutations in childhood acute myeloid leukemia
por: Braoudaki, Maria, et al.
Publicado: (2010)

NPM1 Deletion Is Associated with Gross Chromosomal Rearrangements in Leukemia
por: La Starza, Roberta, et al.
Publicado: (2010)

Current Development and Application of Anaerobic Glycolytic Enzymes in Urothelial Cancer
por: Yang, Yi-Fang, et al.
Publicado: (2021)

Coordinate Modulation of Glycolytic Enzymes and OXPHOS by Imatinib in BCR-ABL Driven Chronic Myelogenous Leukemia Cells
por: De Rosa, Viviana, et al.
Publicado: (2019)

Expression of glycolytic enzymes in ovarian cancers and evaluation of the glycolytic pathway as a strategy for ovarian cancer treatment
por: Xintaropoulou, Chrysi, et al.
Publicado: (2018)

Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia
por: Hirsch, Susanne, et al.
Publicado: (2017)

Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations
por: Mariotti, Benedetta, et al.
Publicado: (2019)

Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation
por: Cocciardi, Sibylle, et al.
Publicado: (2019)

The role of NPM1 alternative splicing in patients with chronic lymphocytic leukemia
por: Szelest, Monika, et al.
Publicado: (2022)

Identification of a novel NPM1 mutation in acute myeloid leukemia
por: Yao, Yiyi, et al.
Publicado: (2023)

Acute myeloid leukemia with concurrent NPM1 and RUNX1 mutations
por: Zuo, Zhuang, et al.
Publicado: (2023)

ENOblock Does Not Inhibit the Activity of the Glycolytic Enzyme Enolase
por: Satani, Nikunj, et al.
Publicado: (2016)

Exploring Non-Metabolic Functions of Glycolytic Enzymes in Immunity
por: Seki, Scott M., et al.
Publicado: (2017)

Resistance to anoikis in transcoelomic shedding: the role of glycolytic enzymes
por: Wilson, Robert B., et al.
Publicado: (2019)

NPM1A in Plasma is a Potential Prognostic Biomarker in Acute Myeloid Leukemia
por: Sun, Chengming, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ug4cbdv7dlf29ie4phjt9hmual