PCAT-1: A Novel Oncogenic Long Non-Coding RNA in Human Cancers

Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides (nts) without obvious protein coding potential. lncRNAs act as multiple roles in biological processes of diseases, especially carcinomas. Prostate cancer associated transcript-1 (PCAT-1) is an oncogenic lncRNA that identified...

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Detalles Bibliográficos
Autores principales: Xiong, Tiefu, Li, Jianfa, Chen, Fangfang, Zhang, Fangting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429018/
https://www.ncbi.nlm.nih.gov/pubmed/30906215
http://dx.doi.org/10.7150/ijbs.30970
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author Xiong, Tiefu
Li, Jianfa
Chen, Fangfang
Zhang, Fangting
author_facet Xiong, Tiefu
Li, Jianfa
Chen, Fangfang
Zhang, Fangting
author_sort Xiong, Tiefu
collection PubMed
description Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides (nts) without obvious protein coding potential. lncRNAs act as multiple roles in biological processes of diseases, especially carcinomas. Prostate cancer associated transcript-1 (PCAT-1) is an oncogenic lncRNA that identified by RNA-Sequence in prostate cancer. High expression of PCAT-1 is observed in different types of cancers, including prostate cancer, colorectal cancer, hepatocellular cancer and gastric cancer. High expressed PCAT-1 is correlated with poor overall survival. Furthermore, PCAT-1 regulates cancer cell proliferation, apoptosis, migration and invasion. Additionally, PCAT-1 is involved in EMT and Wnt/β-catenin-signaling pathway. In this review, we focus on the implication of PCAT-1 in human cancers.
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spelling pubmed-64290182019-03-22 PCAT-1: A Novel Oncogenic Long Non-Coding RNA in Human Cancers Xiong, Tiefu Li, Jianfa Chen, Fangfang Zhang, Fangting Int J Biol Sci Review Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides (nts) without obvious protein coding potential. lncRNAs act as multiple roles in biological processes of diseases, especially carcinomas. Prostate cancer associated transcript-1 (PCAT-1) is an oncogenic lncRNA that identified by RNA-Sequence in prostate cancer. High expression of PCAT-1 is observed in different types of cancers, including prostate cancer, colorectal cancer, hepatocellular cancer and gastric cancer. High expressed PCAT-1 is correlated with poor overall survival. Furthermore, PCAT-1 regulates cancer cell proliferation, apoptosis, migration and invasion. Additionally, PCAT-1 is involved in EMT and Wnt/β-catenin-signaling pathway. In this review, we focus on the implication of PCAT-1 in human cancers. Ivyspring International Publisher 2019-03-01 /pmc/articles/PMC6429018/ /pubmed/30906215 http://dx.doi.org/10.7150/ijbs.30970 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Xiong, Tiefu
Li, Jianfa
Chen, Fangfang
Zhang, Fangting
PCAT-1: A Novel Oncogenic Long Non-Coding RNA in Human Cancers
title PCAT-1: A Novel Oncogenic Long Non-Coding RNA in Human Cancers
title_full PCAT-1: A Novel Oncogenic Long Non-Coding RNA in Human Cancers
title_fullStr PCAT-1: A Novel Oncogenic Long Non-Coding RNA in Human Cancers
title_full_unstemmed PCAT-1: A Novel Oncogenic Long Non-Coding RNA in Human Cancers
title_short PCAT-1: A Novel Oncogenic Long Non-Coding RNA in Human Cancers
title_sort pcat-1: a novel oncogenic long non-coding rna in human cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429018/
https://www.ncbi.nlm.nih.gov/pubmed/30906215
http://dx.doi.org/10.7150/ijbs.30970
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AT chenfangfang pcat1anoveloncogeniclongnoncodingrnainhumancancers
AT zhangfangting pcat1anoveloncogeniclongnoncodingrnainhumancancers

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