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Mechanisms of PKC-Mediated Enhancement of HIF-1α Activity and its Inhibition by Vitamin K2 in Hepatocellular Carcinoma Cells

Hypoxia-inducible factor 1 (HIF-1) plays important roles in cancer cell biology. HIF-1α is reportedly activated by several factors, including protein kinase C (PKC), in addition to hypoxia. We investigated the role of PKC isoforms and the effects of vitamin K2 (VK2) in the activation process of HIF-...

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Detalles Bibliográficos
Autores principales:	Xia, Jinghe, Ozaki, Iwata, Matsuhashi, Sachiko, Kuwashiro, Takuya, Takahashi, Hirokazu, Anzai, Keizo, Mizuta, Toshihiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429062/ https://www.ncbi.nlm.nih.gov/pubmed/30813635 http://dx.doi.org/10.3390/ijms20051022

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