Practical Microwave Synthesis of Carbazole Aldehydes for the Development of DNA-Binding Ligands

Microwave formylation of carbazole derivatives was investigated and 3-monoaldehydes were obtained in high yield. A potential DNA-binding ligand, 3-[(3-ethyl)-2-vinylbenzothiazolium]-9-N-ethyl carbazole iodide, was synthesized and characterized including spectral properties (UV-Vis absorption and flu...

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Autores principales: Głuszyńska, Agata, Juskowiak, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429063/
https://www.ncbi.nlm.nih.gov/pubmed/30857275
http://dx.doi.org/10.3390/molecules24050965
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author Głuszyńska, Agata
Juskowiak, Bernard
author_facet Głuszyńska, Agata
Juskowiak, Bernard
author_sort Głuszyńska, Agata
collection PubMed
description Microwave formylation of carbazole derivatives was investigated and 3-monoaldehydes were obtained in high yield. A potential DNA-binding ligand, 3-[(3-ethyl)-2-vinylbenzothiazolium]-9-N-ethyl carbazole iodide, was synthesized and characterized including spectral properties (UV-Vis absorption and fluorescence spectra). The binding selectivity and affinity of three carbazole ligands for double-stranded and G-quadruplex DNA structures were studied using a competitive dialysis method in sodium- and potassium-containing buffer solutions.
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spelling pubmed-64290632019-04-15 Practical Microwave Synthesis of Carbazole Aldehydes for the Development of DNA-Binding Ligands Głuszyńska, Agata Juskowiak, Bernard Molecules Article Microwave formylation of carbazole derivatives was investigated and 3-monoaldehydes were obtained in high yield. A potential DNA-binding ligand, 3-[(3-ethyl)-2-vinylbenzothiazolium]-9-N-ethyl carbazole iodide, was synthesized and characterized including spectral properties (UV-Vis absorption and fluorescence spectra). The binding selectivity and affinity of three carbazole ligands for double-stranded and G-quadruplex DNA structures were studied using a competitive dialysis method in sodium- and potassium-containing buffer solutions. MDPI 2019-03-09 /pmc/articles/PMC6429063/ /pubmed/30857275 http://dx.doi.org/10.3390/molecules24050965 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Głuszyńska, Agata
Juskowiak, Bernard
Practical Microwave Synthesis of Carbazole Aldehydes for the Development of DNA-Binding Ligands
title Practical Microwave Synthesis of Carbazole Aldehydes for the Development of DNA-Binding Ligands
title_full Practical Microwave Synthesis of Carbazole Aldehydes for the Development of DNA-Binding Ligands
title_fullStr Practical Microwave Synthesis of Carbazole Aldehydes for the Development of DNA-Binding Ligands
title_full_unstemmed Practical Microwave Synthesis of Carbazole Aldehydes for the Development of DNA-Binding Ligands
title_short Practical Microwave Synthesis of Carbazole Aldehydes for the Development of DNA-Binding Ligands
title_sort practical microwave synthesis of carbazole aldehydes for the development of dna-binding ligands
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429063/
https://www.ncbi.nlm.nih.gov/pubmed/30857275
http://dx.doi.org/10.3390/molecules24050965
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