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Plasma Levels of Preβ1-HDL Are Significantly Elevated in Non-Dialyzed Patients with Advanced Stages of Chronic Kidney Disease

In chronic kidney disease (CKD), the level of high-density lipoprotein (HDL) decreases markedly, but there is no strong inverse relationship between HDL-cholesterol (HDL-C) and cardiovascular diseases. This indicates that not only the HDL-C level, but also the other quantitative changes in the HDL p...

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Autores principales: Kuchta, Agnieszka, Ćwiklińska, Agnieszka, Czaplińska, Monika, Wieczorek, Ewa, Kortas-Stempak, Barbara, Gliwińska, Anna, Dąbkowski, Kamil, Sałaga-Zaleska, Kornelia, Mickiewicz, Agnieszka, Dębska-Ślizień, Alicja, Król, Ewa, Jankowski, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429079/
https://www.ncbi.nlm.nih.gov/pubmed/30857306
http://dx.doi.org/10.3390/ijms20051202
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author Kuchta, Agnieszka
Ćwiklińska, Agnieszka
Czaplińska, Monika
Wieczorek, Ewa
Kortas-Stempak, Barbara
Gliwińska, Anna
Dąbkowski, Kamil
Sałaga-Zaleska, Kornelia
Mickiewicz, Agnieszka
Dębska-Ślizień, Alicja
Król, Ewa
Jankowski, Maciej
author_facet Kuchta, Agnieszka
Ćwiklińska, Agnieszka
Czaplińska, Monika
Wieczorek, Ewa
Kortas-Stempak, Barbara
Gliwińska, Anna
Dąbkowski, Kamil
Sałaga-Zaleska, Kornelia
Mickiewicz, Agnieszka
Dębska-Ślizień, Alicja
Król, Ewa
Jankowski, Maciej
author_sort Kuchta, Agnieszka
collection PubMed
description In chronic kidney disease (CKD), the level of high-density lipoprotein (HDL) decreases markedly, but there is no strong inverse relationship between HDL-cholesterol (HDL-C) and cardiovascular diseases. This indicates that not only the HDL-C level, but also the other quantitative changes in the HDL particles can influence the protective functionality of these particles, and can play a key role in the increase of cardiovascular risk in CKD patients. The aim of the present study was the evaluation of the parameters that may give additional information about the HDL particles in the course of progressing CKD. For this purpose, we analyzed the concentrations of HDL containing apolipoprotein A-I without apolipoprotein A-II (LpA-I), preβ1-HDL, and myeloperoxidase (MPO), and the activity of paraoxonase-1 (PON-1) in 68 patients at various stages of CKD. The concentration of HDL cholesterol, MPO, PON-1, and lecithin-cholesterol acyltransferase (LCAT) activity were similar in all of the analyzed stages of CKD. We did not notice significant changes in the LpA-I concentrations in the following stages of CKD (3a CKD stage: 57 ± 19; 3b CKD stage: 54 ± 15; 4 CKD stage: 52 ± 14; p = 0.49). We found, however, that the preβ1-HDL concentration and preβ1-HDL/LpA-I ratio increased along with the progress of CKD, and were inversely correlated with the estimated glomerular filtration rate (eGFR), even after adjusting for age, gender, triacylglycerols (TAG), HDL cholesterol, and statin therapy (β = −0.41, p < 0.001; β = −0.33, p = 0.001, respectively). Our results support the earlier hypothesis that kidney disease leads to the modification of HDL particles, and show that the preβ1-HDL concentration is significantly elevated in non-dialyzed patients with advanced stages of CKD.
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spelling pubmed-64290792019-04-10 Plasma Levels of Preβ1-HDL Are Significantly Elevated in Non-Dialyzed Patients with Advanced Stages of Chronic Kidney Disease Kuchta, Agnieszka Ćwiklińska, Agnieszka Czaplińska, Monika Wieczorek, Ewa Kortas-Stempak, Barbara Gliwińska, Anna Dąbkowski, Kamil Sałaga-Zaleska, Kornelia Mickiewicz, Agnieszka Dębska-Ślizień, Alicja Król, Ewa Jankowski, Maciej Int J Mol Sci Article In chronic kidney disease (CKD), the level of high-density lipoprotein (HDL) decreases markedly, but there is no strong inverse relationship between HDL-cholesterol (HDL-C) and cardiovascular diseases. This indicates that not only the HDL-C level, but also the other quantitative changes in the HDL particles can influence the protective functionality of these particles, and can play a key role in the increase of cardiovascular risk in CKD patients. The aim of the present study was the evaluation of the parameters that may give additional information about the HDL particles in the course of progressing CKD. For this purpose, we analyzed the concentrations of HDL containing apolipoprotein A-I without apolipoprotein A-II (LpA-I), preβ1-HDL, and myeloperoxidase (MPO), and the activity of paraoxonase-1 (PON-1) in 68 patients at various stages of CKD. The concentration of HDL cholesterol, MPO, PON-1, and lecithin-cholesterol acyltransferase (LCAT) activity were similar in all of the analyzed stages of CKD. We did not notice significant changes in the LpA-I concentrations in the following stages of CKD (3a CKD stage: 57 ± 19; 3b CKD stage: 54 ± 15; 4 CKD stage: 52 ± 14; p = 0.49). We found, however, that the preβ1-HDL concentration and preβ1-HDL/LpA-I ratio increased along with the progress of CKD, and were inversely correlated with the estimated glomerular filtration rate (eGFR), even after adjusting for age, gender, triacylglycerols (TAG), HDL cholesterol, and statin therapy (β = −0.41, p < 0.001; β = −0.33, p = 0.001, respectively). Our results support the earlier hypothesis that kidney disease leads to the modification of HDL particles, and show that the preβ1-HDL concentration is significantly elevated in non-dialyzed patients with advanced stages of CKD. MDPI 2019-03-09 /pmc/articles/PMC6429079/ /pubmed/30857306 http://dx.doi.org/10.3390/ijms20051202 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kuchta, Agnieszka
Ćwiklińska, Agnieszka
Czaplińska, Monika
Wieczorek, Ewa
Kortas-Stempak, Barbara
Gliwińska, Anna
Dąbkowski, Kamil
Sałaga-Zaleska, Kornelia
Mickiewicz, Agnieszka
Dębska-Ślizień, Alicja
Król, Ewa
Jankowski, Maciej
Plasma Levels of Preβ1-HDL Are Significantly Elevated in Non-Dialyzed Patients with Advanced Stages of Chronic Kidney Disease
title Plasma Levels of Preβ1-HDL Are Significantly Elevated in Non-Dialyzed Patients with Advanced Stages of Chronic Kidney Disease
title_full Plasma Levels of Preβ1-HDL Are Significantly Elevated in Non-Dialyzed Patients with Advanced Stages of Chronic Kidney Disease
title_fullStr Plasma Levels of Preβ1-HDL Are Significantly Elevated in Non-Dialyzed Patients with Advanced Stages of Chronic Kidney Disease
title_full_unstemmed Plasma Levels of Preβ1-HDL Are Significantly Elevated in Non-Dialyzed Patients with Advanced Stages of Chronic Kidney Disease
title_short Plasma Levels of Preβ1-HDL Are Significantly Elevated in Non-Dialyzed Patients with Advanced Stages of Chronic Kidney Disease
title_sort plasma levels of preβ1-hdl are significantly elevated in non-dialyzed patients with advanced stages of chronic kidney disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429079/
https://www.ncbi.nlm.nih.gov/pubmed/30857306
http://dx.doi.org/10.3390/ijms20051202
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