Cargando…
Natural Products Containing ‘Rare’ Organophosphorus Functional Groups
Phosphorous-containing molecules are essential constituents of all living cells. While the phosphate functional group is very common in small molecule natural products, nucleic acids, and as chemical modification in protein and peptides, phosphorous can form P–N (phosphoramidate), P–S (phosphorothio...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429109/ https://www.ncbi.nlm.nih.gov/pubmed/30823503 http://dx.doi.org/10.3390/molecules24050866 |
_version_ | 1783405521260249088 |
---|---|
author | Petkowski, Janusz J. Bains, William Seager, Sara |
author_facet | Petkowski, Janusz J. Bains, William Seager, Sara |
author_sort | Petkowski, Janusz J. |
collection | PubMed |
description | Phosphorous-containing molecules are essential constituents of all living cells. While the phosphate functional group is very common in small molecule natural products, nucleic acids, and as chemical modification in protein and peptides, phosphorous can form P–N (phosphoramidate), P–S (phosphorothioate), and P–C (e.g., phosphonate and phosphinate) linkages. While rare, these moieties play critical roles in many processes and in all forms of life. In this review we thoroughly categorize P–N, P–S, and P–C natural organophosphorus compounds. Information on biological source, biological activity, and biosynthesis is included, if known. This review also summarizes the role of phosphorylation on unusual amino acids in proteins (N- and S-phosphorylation) and reviews the natural phosphorothioate (P–S) and phosphoramidate (P–N) modifications of DNA and nucleotides with an emphasis on their role in the metabolism of the cell. We challenge the commonly held notion that nonphosphate organophosphorus functional groups are an oddity of biochemistry, with no central role in the metabolism of the cell. We postulate that the extent of utilization of some phosphorus groups by life, especially those containing P–N bonds, is likely severely underestimated and has been largely overlooked, mainly due to the technological limitations in their detection and analysis. |
format | Online Article Text |
id | pubmed-6429109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64291092019-04-15 Natural Products Containing ‘Rare’ Organophosphorus Functional Groups Petkowski, Janusz J. Bains, William Seager, Sara Molecules Review Phosphorous-containing molecules are essential constituents of all living cells. While the phosphate functional group is very common in small molecule natural products, nucleic acids, and as chemical modification in protein and peptides, phosphorous can form P–N (phosphoramidate), P–S (phosphorothioate), and P–C (e.g., phosphonate and phosphinate) linkages. While rare, these moieties play critical roles in many processes and in all forms of life. In this review we thoroughly categorize P–N, P–S, and P–C natural organophosphorus compounds. Information on biological source, biological activity, and biosynthesis is included, if known. This review also summarizes the role of phosphorylation on unusual amino acids in proteins (N- and S-phosphorylation) and reviews the natural phosphorothioate (P–S) and phosphoramidate (P–N) modifications of DNA and nucleotides with an emphasis on their role in the metabolism of the cell. We challenge the commonly held notion that nonphosphate organophosphorus functional groups are an oddity of biochemistry, with no central role in the metabolism of the cell. We postulate that the extent of utilization of some phosphorus groups by life, especially those containing P–N bonds, is likely severely underestimated and has been largely overlooked, mainly due to the technological limitations in their detection and analysis. MDPI 2019-02-28 /pmc/articles/PMC6429109/ /pubmed/30823503 http://dx.doi.org/10.3390/molecules24050866 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Petkowski, Janusz J. Bains, William Seager, Sara Natural Products Containing ‘Rare’ Organophosphorus Functional Groups |
title | Natural Products Containing ‘Rare’ Organophosphorus Functional Groups |
title_full | Natural Products Containing ‘Rare’ Organophosphorus Functional Groups |
title_fullStr | Natural Products Containing ‘Rare’ Organophosphorus Functional Groups |
title_full_unstemmed | Natural Products Containing ‘Rare’ Organophosphorus Functional Groups |
title_short | Natural Products Containing ‘Rare’ Organophosphorus Functional Groups |
title_sort | natural products containing ‘rare’ organophosphorus functional groups |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429109/ https://www.ncbi.nlm.nih.gov/pubmed/30823503 http://dx.doi.org/10.3390/molecules24050866 |
work_keys_str_mv | AT petkowskijanuszj naturalproductscontainingrareorganophosphorusfunctionalgroups AT bainswilliam naturalproductscontainingrareorganophosphorusfunctionalgroups AT seagersara naturalproductscontainingrareorganophosphorusfunctionalgroups |