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Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption

Maternal diet modifies epigenetic programming in offspring, a potentially critical factor in the immune dysregulation of modern societies. We previously found that prenatal fish oil supplementation affects neonatal T-cell histone acetylation of genes implicated in adaptive immunity including PRKCZ,...

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Autores principales: Acevedo, Nathalie, Frumento, Paolo, Harb, Hani, Alashkar Alhamwe, Bilal, Johansson, Catharina, Eick, Lisa, Alm, Johan, Renz, Harald, Scheynius, Annika, Potaczek, Daniel P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429118/
https://www.ncbi.nlm.nih.gov/pubmed/30823645
http://dx.doi.org/10.3390/ijms20051060
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author Acevedo, Nathalie
Frumento, Paolo
Harb, Hani
Alashkar Alhamwe, Bilal
Johansson, Catharina
Eick, Lisa
Alm, Johan
Renz, Harald
Scheynius, Annika
Potaczek, Daniel P.
author_facet Acevedo, Nathalie
Frumento, Paolo
Harb, Hani
Alashkar Alhamwe, Bilal
Johansson, Catharina
Eick, Lisa
Alm, Johan
Renz, Harald
Scheynius, Annika
Potaczek, Daniel P.
author_sort Acevedo, Nathalie
collection PubMed
description Maternal diet modifies epigenetic programming in offspring, a potentially critical factor in the immune dysregulation of modern societies. We previously found that prenatal fish oil supplementation affects neonatal T-cell histone acetylation of genes implicated in adaptive immunity including PRKCZ, IL13, and TBX21. In this study, we measured H3 and H4 histone acetylation levels by chromatin immunoprecipitation in 173 term placentas collected in the prospective birth cohort, ALADDIN, in which information on lifestyle and diet is thoroughly recorded. In anthroposophic families, regular olive oil usage during pregnancy was associated with increased H3 acetylation at FOXP3 (p = 0.004), IL10RA (p = 0.008), and IL7R (p = 0.007) promoters, which remained significant after adjustment by offspring gender. Furthermore, maternal fish consumption was associated with increased H4 acetylation at the CD14 gene in placentas of female offspring (p = 0.009). In conclusion, prenatal olive oil intake can affect placental histone acetylation in immune regulatory genes, confirming previously observed pro-acetylation effects of olive oil polyphenols. The association with fish consumption may implicate ω-3 polyunsaturated fatty acids present in fish oil. Altered histone acetylation in placentas from mothers who regularly include fish or olive oil in their diets could influence immune priming in the newborn.
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spelling pubmed-64291182019-04-10 Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption Acevedo, Nathalie Frumento, Paolo Harb, Hani Alashkar Alhamwe, Bilal Johansson, Catharina Eick, Lisa Alm, Johan Renz, Harald Scheynius, Annika Potaczek, Daniel P. Int J Mol Sci Article Maternal diet modifies epigenetic programming in offspring, a potentially critical factor in the immune dysregulation of modern societies. We previously found that prenatal fish oil supplementation affects neonatal T-cell histone acetylation of genes implicated in adaptive immunity including PRKCZ, IL13, and TBX21. In this study, we measured H3 and H4 histone acetylation levels by chromatin immunoprecipitation in 173 term placentas collected in the prospective birth cohort, ALADDIN, in which information on lifestyle and diet is thoroughly recorded. In anthroposophic families, regular olive oil usage during pregnancy was associated with increased H3 acetylation at FOXP3 (p = 0.004), IL10RA (p = 0.008), and IL7R (p = 0.007) promoters, which remained significant after adjustment by offspring gender. Furthermore, maternal fish consumption was associated with increased H4 acetylation at the CD14 gene in placentas of female offspring (p = 0.009). In conclusion, prenatal olive oil intake can affect placental histone acetylation in immune regulatory genes, confirming previously observed pro-acetylation effects of olive oil polyphenols. The association with fish consumption may implicate ω-3 polyunsaturated fatty acids present in fish oil. Altered histone acetylation in placentas from mothers who regularly include fish or olive oil in their diets could influence immune priming in the newborn. MDPI 2019-03-01 /pmc/articles/PMC6429118/ /pubmed/30823645 http://dx.doi.org/10.3390/ijms20051060 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Acevedo, Nathalie
Frumento, Paolo
Harb, Hani
Alashkar Alhamwe, Bilal
Johansson, Catharina
Eick, Lisa
Alm, Johan
Renz, Harald
Scheynius, Annika
Potaczek, Daniel P.
Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption
title Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption
title_full Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption
title_fullStr Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption
title_full_unstemmed Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption
title_short Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption
title_sort histone acetylation of immune regulatory genes in human placenta in association with maternal intake of olive oil and fish consumption
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429118/
https://www.ncbi.nlm.nih.gov/pubmed/30823645
http://dx.doi.org/10.3390/ijms20051060
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