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Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer

Pleiotropic effects of curcumin have been the subject of intensive research. The interest in this molecule for preventive medicine may further increase because of its potential to modulate inflamm-aging. Although direct data related to its effect on inflamm-aging does not exist, there is a strong po...

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Autores principales: Kujundžić, Renata Novak, Stepanić, Višnja, Milković, Lidija, Gašparović, Ana Čipak, Tomljanović, Marko, Trošelj, Koraljka Gall
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429141/
https://www.ncbi.nlm.nih.gov/pubmed/30857125
http://dx.doi.org/10.3390/ijms20051180
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author Kujundžić, Renata Novak
Stepanić, Višnja
Milković, Lidija
Gašparović, Ana Čipak
Tomljanović, Marko
Trošelj, Koraljka Gall
author_facet Kujundžić, Renata Novak
Stepanić, Višnja
Milković, Lidija
Gašparović, Ana Čipak
Tomljanović, Marko
Trošelj, Koraljka Gall
author_sort Kujundžić, Renata Novak
collection PubMed
description Pleiotropic effects of curcumin have been the subject of intensive research. The interest in this molecule for preventive medicine may further increase because of its potential to modulate inflamm-aging. Although direct data related to its effect on inflamm-aging does not exist, there is a strong possibility that its well-known anti-inflammatory properties may be relevant to this phenomenon. Curcumin’s binding to various proteins, which was shown to be dependent on cellular oxidative status, is yet another feature for exploration in depth. Finally, the binding of curcumin to various metabolic enzymes is crucial to curcumin’s interference with powerful metabolic machinery, and can also be crucial for metabolic reprogramming of cancer cells. This review offers a synthesis and functional links that may better explain older data, some observational, in light of the most recent findings on curcumin. Our focus is on its modes of action that have the potential to alleviate specific morbidities of the 21st century.
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spelling pubmed-64291412019-04-10 Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer Kujundžić, Renata Novak Stepanić, Višnja Milković, Lidija Gašparović, Ana Čipak Tomljanović, Marko Trošelj, Koraljka Gall Int J Mol Sci Review Pleiotropic effects of curcumin have been the subject of intensive research. The interest in this molecule for preventive medicine may further increase because of its potential to modulate inflamm-aging. Although direct data related to its effect on inflamm-aging does not exist, there is a strong possibility that its well-known anti-inflammatory properties may be relevant to this phenomenon. Curcumin’s binding to various proteins, which was shown to be dependent on cellular oxidative status, is yet another feature for exploration in depth. Finally, the binding of curcumin to various metabolic enzymes is crucial to curcumin’s interference with powerful metabolic machinery, and can also be crucial for metabolic reprogramming of cancer cells. This review offers a synthesis and functional links that may better explain older data, some observational, in light of the most recent findings on curcumin. Our focus is on its modes of action that have the potential to alleviate specific morbidities of the 21st century. MDPI 2019-03-08 /pmc/articles/PMC6429141/ /pubmed/30857125 http://dx.doi.org/10.3390/ijms20051180 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kujundžić, Renata Novak
Stepanić, Višnja
Milković, Lidija
Gašparović, Ana Čipak
Tomljanović, Marko
Trošelj, Koraljka Gall
Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer
title Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer
title_full Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer
title_fullStr Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer
title_full_unstemmed Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer
title_short Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer
title_sort curcumin and its potential for systemic targeting of inflamm-aging and metabolic reprogramming in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429141/
https://www.ncbi.nlm.nih.gov/pubmed/30857125
http://dx.doi.org/10.3390/ijms20051180
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