New Caffeoylquinic Acid Derivatives and Flavanone Glycoside from the Flowers of Chrysanthemum morifolium and Their Bioactivities

The Chrysanthemum morifolium flower is widely used in China and Japan as a food, beverage, and medicine for many diseases. In our work, two new caffeoylquinic acid derivatives (1, 2), a new flavanone glycoside (3), and six reported flavanones (4–9) were isolated and identified from the flowers of C....

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Detalles Bibliográficos
Autores principales: Yang, Peng-Fei, Yang, Ya-Nan, He, Chun-Yu, Chen, Zhi-Fei, Yuan, Qi-Shan, Zhao, Sheng-Chen, Fu, Yu-Feng, Zhang, Pei-Cheng, Mao, Duo-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429231/
https://www.ncbi.nlm.nih.gov/pubmed/30823375
http://dx.doi.org/10.3390/molecules24050850
Descripción
Sumario:The Chrysanthemum morifolium flower is widely used in China and Japan as a food, beverage, and medicine for many diseases. In our work, two new caffeoylquinic acid derivatives (1, 2), a new flavanone glycoside (3), and six reported flavanones (4–9) were isolated and identified from the flowers of C. morifolium. The chemical structures of all isolates were elucidated by the analysis of comprehensive spectroscopic data as well as by comparison with previously reported data. The isolated constituents 1–8 were evaluated for their neuroprotective activity, and compounds 3 and 4 displayed neuroprotective effects against hydrogen peroxide-induced neurotoxicity in human neuroblastoma SH-SY5Y cells.

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