In Silico Methods for the Discovery of Orthosteric GABA(B) Receptor Compounds

The GABA(B) receptor (GABA(B)-R) is a heterodimeric class C G protein-coupled receptor comprised of the GABA(B1a/b) and GABA(B2) subunits. The endogenous orthosteric agonist γ-amino-butyric acid (GABA) binds within the extracellular Venus flytrap (VFT) domain of the GABA(B1a/b) subunit. The receptor...

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Detalles Bibliográficos
Autores principales: Evenseth, Linn M., Warszycki, Dawid, Bojarski, Andrzej J., Gabrielsen, Mari, Sylte, Ingebrigt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429233/
https://www.ncbi.nlm.nih.gov/pubmed/30866507
http://dx.doi.org/10.3390/molecules24050935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429233/
https://www.ncbi.nlm.nih.gov/pubmed/30866507
http://dx.doi.org/10.3390/molecules24050935

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