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Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring

A variety of environmental factors contribute significantly to age-related cognitive decline and memory impairment in Alzheimer’s Disease (AD) and other neurodegenerative diseases. Nutrition can alter epigenetics, improving health outcomes, which can be transmitted across generations; this process i...

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Autores principales: Izquierdo, Vanesa, Palomera-Ávalos, Verónica, López-Ruiz, Sergio, Canudas, Anna-Maria, Pallàs, Mercè, Griñán-Ferré, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429303/
https://www.ncbi.nlm.nih.gov/pubmed/30845644
http://dx.doi.org/10.3390/ijms20051134
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author Izquierdo, Vanesa
Palomera-Ávalos, Verónica
López-Ruiz, Sergio
Canudas, Anna-Maria
Pallàs, Mercè
Griñán-Ferré, Christian
author_facet Izquierdo, Vanesa
Palomera-Ávalos, Verónica
López-Ruiz, Sergio
Canudas, Anna-Maria
Pallàs, Mercè
Griñán-Ferré, Christian
author_sort Izquierdo, Vanesa
collection PubMed
description A variety of environmental factors contribute significantly to age-related cognitive decline and memory impairment in Alzheimer’s Disease (AD) and other neurodegenerative diseases. Nutrition can alter epigenetics, improving health outcomes, which can be transmitted across generations; this process is called epigenetic inheritance. We investigate the beneficial effects of maternal resveratrol supplementation in the direct exposed F1 generation and the transgenerational F2 generation. The offspring was generated from females Senescence Accelerated Mouse-Prone (SAMP8) fed a resveratrol-enriched diet for two months prior to mating. Object novel recognition and Morris Water Maze (MWM) demonstrated improvements in cognition in the 6-month-old F1 and F2 generations from resveratrol fed mothers. A significant increase in global DNA methylation with a decrease in hydroxymethylation in F1 and F2 were found. Accordingly, Dnmt3a/b and Tet2 gene expression changed. Methylation levels of Nrf2 and NF-kβ genes promoters raised in offspring, inducing changes in target genes expression, as well as hydrogen peroxide levels. Offspring that resulted from a resveratrol fed mother showed increase AMPKα activation, mTOR inhibition, and an increase in Pgc-1α gene expression and Beclin-1 protein levels. Endoplasmic reticulum stress sensors were found changed both in F1 and F2 generations. Overall, our results demonstrated that maternal resveratrol supplementation could prevent cognitive impairment in the SAMP8 mice offspring through epigenetic changes and cell signaling pathways.
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spelling pubmed-64293032019-04-10 Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring Izquierdo, Vanesa Palomera-Ávalos, Verónica López-Ruiz, Sergio Canudas, Anna-Maria Pallàs, Mercè Griñán-Ferré, Christian Int J Mol Sci Article A variety of environmental factors contribute significantly to age-related cognitive decline and memory impairment in Alzheimer’s Disease (AD) and other neurodegenerative diseases. Nutrition can alter epigenetics, improving health outcomes, which can be transmitted across generations; this process is called epigenetic inheritance. We investigate the beneficial effects of maternal resveratrol supplementation in the direct exposed F1 generation and the transgenerational F2 generation. The offspring was generated from females Senescence Accelerated Mouse-Prone (SAMP8) fed a resveratrol-enriched diet for two months prior to mating. Object novel recognition and Morris Water Maze (MWM) demonstrated improvements in cognition in the 6-month-old F1 and F2 generations from resveratrol fed mothers. A significant increase in global DNA methylation with a decrease in hydroxymethylation in F1 and F2 were found. Accordingly, Dnmt3a/b and Tet2 gene expression changed. Methylation levels of Nrf2 and NF-kβ genes promoters raised in offspring, inducing changes in target genes expression, as well as hydrogen peroxide levels. Offspring that resulted from a resveratrol fed mother showed increase AMPKα activation, mTOR inhibition, and an increase in Pgc-1α gene expression and Beclin-1 protein levels. Endoplasmic reticulum stress sensors were found changed both in F1 and F2 generations. Overall, our results demonstrated that maternal resveratrol supplementation could prevent cognitive impairment in the SAMP8 mice offspring through epigenetic changes and cell signaling pathways. MDPI 2019-03-06 /pmc/articles/PMC6429303/ /pubmed/30845644 http://dx.doi.org/10.3390/ijms20051134 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Izquierdo, Vanesa
Palomera-Ávalos, Verónica
López-Ruiz, Sergio
Canudas, Anna-Maria
Pallàs, Mercè
Griñán-Ferré, Christian
Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring
title Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring
title_full Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring
title_fullStr Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring
title_full_unstemmed Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring
title_short Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring
title_sort maternal resveratrol supplementation prevents cognitive decline in senescent mice offspring
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429303/
https://www.ncbi.nlm.nih.gov/pubmed/30845644
http://dx.doi.org/10.3390/ijms20051134
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