Cytarabine-Resistant FLT3-ITD Leukemia Cells are Associated with TP53 Mutation and Multiple Pathway Alterations—Possible Therapeutic Efficacy of Cabozantinib

Internal tandem duplication of FLT3 juxtamembrane domain (FLT3-ITD)-positive acute myeloid leukemia (AML) leads to poor clinical outcomes after chemotherapy. We aimed to establish a cytarabine-resistant line from FLT3-ITD-positive MV4-11 (MV4-11-P) cells and examine the development of resistance. Th...

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Detalles Bibliográficos
Autores principales: Ko, Ya-Chen, Hu, Chung-Yi, Liu, Zheng-Hau, Tien, Hwei-Fang, Ou, Da-Liang, Chien, Hsiung-Fei, Lin, Liang-In
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429333/
https://www.ncbi.nlm.nih.gov/pubmed/30862120
http://dx.doi.org/10.3390/ijms20051230

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