The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy

Herein, a convergent, practicable and first total synthesis of the natural product, (±)-methyl salvianolate A, is reported. The key features of the approach are the use of a Horner–Wadsworth–Emmons reaction and the protection of multiple hydroxyls using silyl protecting groups. The employment of the...

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Detalles Bibliográficos
Autores principales: Wang, Bo, Wang, Liping, Peng, Ying, Pang, Yiying, Xiao, Hesheng, Wang, Xiaoji, Huang, Shuangping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429350/
https://www.ncbi.nlm.nih.gov/pubmed/30871115
http://dx.doi.org/10.3390/molecules24050999
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author Wang, Bo
Wang, Liping
Peng, Ying
Pang, Yiying
Xiao, Hesheng
Wang, Xiaoji
Huang, Shuangping
author_facet Wang, Bo
Wang, Liping
Peng, Ying
Pang, Yiying
Xiao, Hesheng
Wang, Xiaoji
Huang, Shuangping
author_sort Wang, Bo
collection PubMed
description Herein, a convergent, practicable and first total synthesis of the natural product, (±)-methyl salvianolate A, is reported. The key features of the approach are the use of a Horner–Wadsworth–Emmons reaction and the protection of multiple hydroxyls using silyl protecting groups. The employment of the readily removable silyl protecting groups allows the synthesis of (±)-methyl salvianolate A and its derivatives on a reasonably large scale.
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spelling pubmed-64293502019-04-15 The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy Wang, Bo Wang, Liping Peng, Ying Pang, Yiying Xiao, Hesheng Wang, Xiaoji Huang, Shuangping Molecules Article Herein, a convergent, practicable and first total synthesis of the natural product, (±)-methyl salvianolate A, is reported. The key features of the approach are the use of a Horner–Wadsworth–Emmons reaction and the protection of multiple hydroxyls using silyl protecting groups. The employment of the readily removable silyl protecting groups allows the synthesis of (±)-methyl salvianolate A and its derivatives on a reasonably large scale. MDPI 2019-03-12 /pmc/articles/PMC6429350/ /pubmed/30871115 http://dx.doi.org/10.3390/molecules24050999 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Bo
Wang, Liping
Peng, Ying
Pang, Yiying
Xiao, Hesheng
Wang, Xiaoji
Huang, Shuangping
The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy
title The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy
title_full The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy
title_fullStr The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy
title_full_unstemmed The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy
title_short The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy
title_sort first total synthesis of (±)-methyl salvianolate a using a convergent strategy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429350/
https://www.ncbi.nlm.nih.gov/pubmed/30871115
http://dx.doi.org/10.3390/molecules24050999
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