Development of Anthraquinone Analogues as Phosphoglycerate Mutase 1 Inhibitors

Phosphoglycerate mutase 1 (PGAM1) coordinates glycolysis and biosynthesis to promote cancer cell proliferation, and is believed to be a promising target for cancer therapy. Herein, based on the anthraquinone scaffold, we synthesized 31 anthraquinone derivatives and investigated the structure−activit...

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Detalles Bibliográficos
Autores principales: Huang, Ke, Jiang, Lulu, Li, Huiti, Ye, Deyong, Zhou, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429356/
https://www.ncbi.nlm.nih.gov/pubmed/30818883
http://dx.doi.org/10.3390/molecules24050845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429356/
https://www.ncbi.nlm.nih.gov/pubmed/30818883
http://dx.doi.org/10.3390/molecules24050845

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