Weinreb Amides as Directing Groups for Transition Metal-Catalyzed C-H Functionalizations

Weinreb amides are a privileged, multi-functional group with well-established utility in classical synthesis. Recently, several studies have demonstrated the use of Weinreb amides as interesting substrates in transition metal-catalyzed C-H functionalization reactions. Herein, we review this part of...

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Detalles Bibliográficos
Autores principales: Kalepu, Jagadeesh, Pilarski, Lukasz T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429370/
https://www.ncbi.nlm.nih.gov/pubmed/30813564
http://dx.doi.org/10.3390/molecules24050830
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author Kalepu, Jagadeesh
Pilarski, Lukasz T.
author_facet Kalepu, Jagadeesh
Pilarski, Lukasz T.
author_sort Kalepu, Jagadeesh
collection PubMed
description Weinreb amides are a privileged, multi-functional group with well-established utility in classical synthesis. Recently, several studies have demonstrated the use of Weinreb amides as interesting substrates in transition metal-catalyzed C-H functionalization reactions. Herein, we review this part of the literature, including the metal catalysts, transformations explored so far and specific insights from mechanistic studies.
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spelling pubmed-64293702019-04-15 Weinreb Amides as Directing Groups for Transition Metal-Catalyzed C-H Functionalizations Kalepu, Jagadeesh Pilarski, Lukasz T. Molecules Review Weinreb amides are a privileged, multi-functional group with well-established utility in classical synthesis. Recently, several studies have demonstrated the use of Weinreb amides as interesting substrates in transition metal-catalyzed C-H functionalization reactions. Herein, we review this part of the literature, including the metal catalysts, transformations explored so far and specific insights from mechanistic studies. MDPI 2019-02-26 /pmc/articles/PMC6429370/ /pubmed/30813564 http://dx.doi.org/10.3390/molecules24050830 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kalepu, Jagadeesh
Pilarski, Lukasz T.
Weinreb Amides as Directing Groups for Transition Metal-Catalyzed C-H Functionalizations
title Weinreb Amides as Directing Groups for Transition Metal-Catalyzed C-H Functionalizations
title_full Weinreb Amides as Directing Groups for Transition Metal-Catalyzed C-H Functionalizations
title_fullStr Weinreb Amides as Directing Groups for Transition Metal-Catalyzed C-H Functionalizations
title_full_unstemmed Weinreb Amides as Directing Groups for Transition Metal-Catalyzed C-H Functionalizations
title_short Weinreb Amides as Directing Groups for Transition Metal-Catalyzed C-H Functionalizations
title_sort weinreb amides as directing groups for transition metal-catalyzed c-h functionalizations
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429370/
https://www.ncbi.nlm.nih.gov/pubmed/30813564
http://dx.doi.org/10.3390/molecules24050830
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AT pilarskilukaszt weinrebamidesasdirectinggroupsfortransitionmetalcatalyzedchfunctionalizations

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