Gymnotic Delivery of LNA Mixmers Targeting Viral SREs Induces HIV-1 mRNA Degradation

Transcription of the HIV-1 provirus generates a viral pre-mRNA, which is alternatively spliced into more than 50 HIV-1 mRNAs encoding all viral proteins. Regulation of viral alternative splice site usage includes the presence of splicing regulatory elements (SREs) which can dramatically impact RNA e...

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Detalles Bibliográficos
Autores principales: Hillebrand, Frank, Ostermann, Philipp Niklas, Müller, Lisa, Degrandi, Daniel, Erkelenz, Steffen, Widera, Marek, Pfeffer, Klaus, Schaal, Heiner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429378/
https://www.ncbi.nlm.nih.gov/pubmed/30832397
http://dx.doi.org/10.3390/ijms20051088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429378/
https://www.ncbi.nlm.nih.gov/pubmed/30832397
http://dx.doi.org/10.3390/ijms20051088

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