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Knockdown of the TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Sensitizes Glioma Cells to Hypoxia, Irradiation and Temozolomide

The TP53-induced glycolysis and apoptosis regulator (TIGAR) has been shown to decrease glycolysis, to activate the pentose phosphate pathway, and to provide protection against oxidative damage. Hypoxic regions are considered characteristic of glioblastoma and linked with resistance to current treatm...

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Detalles Bibliográficos
Autores principales:	Maurer, Gabriele D., Heller, Sonja, Wanka, Christina, Rieger, Johannes, Steinbach, Joachim P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429390/ https://www.ncbi.nlm.nih.gov/pubmed/30823646 http://dx.doi.org/10.3390/ijms20051061

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