CoREST Complex-Selective Histone Deacetylase Inhibitors Show Prosynaptic Effects and an Improved Safety Profile To Enable Treatment of Synaptopathies

[Image: see text] Synaptic dysfunction is a pathological feature in many neurodegenerative disorders, including Alzheimer’s disease, and synaptic loss correlates closely with cognitive decline. Histone deacetylases (HDACs) are involved in chromatin remodeling and gene expression and have been shown...

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Detalles Bibliográficos
Autores principales: Fuller, Nathan O., Pirone, Antonella, Lynch, Berkley A., Hewitt, Michael C., Quinton, Maria S., McKee, Timothy D., Ivarsson, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429430/
https://www.ncbi.nlm.nih.gov/pubmed/30496686
http://dx.doi.org/10.1021/acschemneuro.8b00620

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429430/
https://www.ncbi.nlm.nih.gov/pubmed/30496686
http://dx.doi.org/10.1021/acschemneuro.8b00620

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