Differential Proteomics Reveals miR-155 as a Novel Indicator of Liver and Spleen Pathology in the Symptomatic Niemann-Pick Disease, Type C1 Mouse Model

Niemann-Pick disease, type C1 (NPC1) is a rare, autosomal recessive, lipid storage disorder caused by mutations in NPC1. As a result, there is accumulation of unesterified cholesterol and sphingolipids in the late endosomal/lysosomal system. Clinically, patients can present with splenomegaly and hep...

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Detalles Bibliográficos
Autores principales: Pergande, Melissa R., Cougnoux, Antony, Rathnayake, Rathnayake A. C., Porter, Forbes D., Cologna, Stephanie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429457/
https://www.ncbi.nlm.nih.gov/pubmed/30870990
http://dx.doi.org/10.3390/molecules24050994

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