Cargando…

Dietary Phytochemicals Targeting Cancer Stem Cells

There is an increasing awareness of the importance of a diet rich in fruits and vegetables for human health. Cancer stem cells (CSCs) are characterized as a subpopulation of cancer cells with aberrant regulation of self-renewal, proliferation or apoptosis leading to cancer progression, invasiveness,...

Descripción completa

Detalles Bibliográficos
Autores principales: Liskova, Alena, Kubatka, Peter, Samec, Marek, Zubor, Pavol, Mlyncek, Milos, Bielik, Tibor, Samuel, Samson Mathews, Zulli, Anthony, Kwon, Taeg Kyu, Büsselberg, Dietrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429493/
https://www.ncbi.nlm.nih.gov/pubmed/30836718
http://dx.doi.org/10.3390/molecules24050899
_version_ 1783405608254308352
author Liskova, Alena
Kubatka, Peter
Samec, Marek
Zubor, Pavol
Mlyncek, Milos
Bielik, Tibor
Samuel, Samson Mathews
Zulli, Anthony
Kwon, Taeg Kyu
Büsselberg, Dietrich
author_facet Liskova, Alena
Kubatka, Peter
Samec, Marek
Zubor, Pavol
Mlyncek, Milos
Bielik, Tibor
Samuel, Samson Mathews
Zulli, Anthony
Kwon, Taeg Kyu
Büsselberg, Dietrich
author_sort Liskova, Alena
collection PubMed
description There is an increasing awareness of the importance of a diet rich in fruits and vegetables for human health. Cancer stem cells (CSCs) are characterized as a subpopulation of cancer cells with aberrant regulation of self-renewal, proliferation or apoptosis leading to cancer progression, invasiveness, metastasis formation, and therapy resistance. Anticancer effects of phytochemicals are also directed to target CSCs. Here we provide a comprehensive review of dietary phytochemicals targeting CSCs. Moreover, we evaluate and summarize studies dealing with effects of dietary phytochemicals on CSCs of various malignancies in preclinical and clinical research. Dietary phytochemicals have a significant impact on CSCs which may be applied in cancer prevention and treatment. However, anticancer effects of plant derived compounds have not yet been fully investigated in clinical research.
format Online
Article
Text
id pubmed-6429493
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-64294932019-04-15 Dietary Phytochemicals Targeting Cancer Stem Cells Liskova, Alena Kubatka, Peter Samec, Marek Zubor, Pavol Mlyncek, Milos Bielik, Tibor Samuel, Samson Mathews Zulli, Anthony Kwon, Taeg Kyu Büsselberg, Dietrich Molecules Review There is an increasing awareness of the importance of a diet rich in fruits and vegetables for human health. Cancer stem cells (CSCs) are characterized as a subpopulation of cancer cells with aberrant regulation of self-renewal, proliferation or apoptosis leading to cancer progression, invasiveness, metastasis formation, and therapy resistance. Anticancer effects of phytochemicals are also directed to target CSCs. Here we provide a comprehensive review of dietary phytochemicals targeting CSCs. Moreover, we evaluate and summarize studies dealing with effects of dietary phytochemicals on CSCs of various malignancies in preclinical and clinical research. Dietary phytochemicals have a significant impact on CSCs which may be applied in cancer prevention and treatment. However, anticancer effects of plant derived compounds have not yet been fully investigated in clinical research. MDPI 2019-03-04 /pmc/articles/PMC6429493/ /pubmed/30836718 http://dx.doi.org/10.3390/molecules24050899 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liskova, Alena
Kubatka, Peter
Samec, Marek
Zubor, Pavol
Mlyncek, Milos
Bielik, Tibor
Samuel, Samson Mathews
Zulli, Anthony
Kwon, Taeg Kyu
Büsselberg, Dietrich
Dietary Phytochemicals Targeting Cancer Stem Cells
title Dietary Phytochemicals Targeting Cancer Stem Cells
title_full Dietary Phytochemicals Targeting Cancer Stem Cells
title_fullStr Dietary Phytochemicals Targeting Cancer Stem Cells
title_full_unstemmed Dietary Phytochemicals Targeting Cancer Stem Cells
title_short Dietary Phytochemicals Targeting Cancer Stem Cells
title_sort dietary phytochemicals targeting cancer stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429493/
https://www.ncbi.nlm.nih.gov/pubmed/30836718
http://dx.doi.org/10.3390/molecules24050899
work_keys_str_mv AT liskovaalena dietaryphytochemicalstargetingcancerstemcells
AT kubatkapeter dietaryphytochemicalstargetingcancerstemcells
AT samecmarek dietaryphytochemicalstargetingcancerstemcells
AT zuborpavol dietaryphytochemicalstargetingcancerstemcells
AT mlyncekmilos dietaryphytochemicalstargetingcancerstemcells
AT bieliktibor dietaryphytochemicalstargetingcancerstemcells
AT samuelsamsonmathews dietaryphytochemicalstargetingcancerstemcells
AT zullianthony dietaryphytochemicalstargetingcancerstemcells
AT kwontaegkyu dietaryphytochemicalstargetingcancerstemcells
AT busselbergdietrich dietaryphytochemicalstargetingcancerstemcells