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Dietary Phytochemicals Targeting Cancer Stem Cells
There is an increasing awareness of the importance of a diet rich in fruits and vegetables for human health. Cancer stem cells (CSCs) are characterized as a subpopulation of cancer cells with aberrant regulation of self-renewal, proliferation or apoptosis leading to cancer progression, invasiveness,...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429493/ https://www.ncbi.nlm.nih.gov/pubmed/30836718 http://dx.doi.org/10.3390/molecules24050899 |
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author | Liskova, Alena Kubatka, Peter Samec, Marek Zubor, Pavol Mlyncek, Milos Bielik, Tibor Samuel, Samson Mathews Zulli, Anthony Kwon, Taeg Kyu Büsselberg, Dietrich |
author_facet | Liskova, Alena Kubatka, Peter Samec, Marek Zubor, Pavol Mlyncek, Milos Bielik, Tibor Samuel, Samson Mathews Zulli, Anthony Kwon, Taeg Kyu Büsselberg, Dietrich |
author_sort | Liskova, Alena |
collection | PubMed |
description | There is an increasing awareness of the importance of a diet rich in fruits and vegetables for human health. Cancer stem cells (CSCs) are characterized as a subpopulation of cancer cells with aberrant regulation of self-renewal, proliferation or apoptosis leading to cancer progression, invasiveness, metastasis formation, and therapy resistance. Anticancer effects of phytochemicals are also directed to target CSCs. Here we provide a comprehensive review of dietary phytochemicals targeting CSCs. Moreover, we evaluate and summarize studies dealing with effects of dietary phytochemicals on CSCs of various malignancies in preclinical and clinical research. Dietary phytochemicals have a significant impact on CSCs which may be applied in cancer prevention and treatment. However, anticancer effects of plant derived compounds have not yet been fully investigated in clinical research. |
format | Online Article Text |
id | pubmed-6429493 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64294932019-04-15 Dietary Phytochemicals Targeting Cancer Stem Cells Liskova, Alena Kubatka, Peter Samec, Marek Zubor, Pavol Mlyncek, Milos Bielik, Tibor Samuel, Samson Mathews Zulli, Anthony Kwon, Taeg Kyu Büsselberg, Dietrich Molecules Review There is an increasing awareness of the importance of a diet rich in fruits and vegetables for human health. Cancer stem cells (CSCs) are characterized as a subpopulation of cancer cells with aberrant regulation of self-renewal, proliferation or apoptosis leading to cancer progression, invasiveness, metastasis formation, and therapy resistance. Anticancer effects of phytochemicals are also directed to target CSCs. Here we provide a comprehensive review of dietary phytochemicals targeting CSCs. Moreover, we evaluate and summarize studies dealing with effects of dietary phytochemicals on CSCs of various malignancies in preclinical and clinical research. Dietary phytochemicals have a significant impact on CSCs which may be applied in cancer prevention and treatment. However, anticancer effects of plant derived compounds have not yet been fully investigated in clinical research. MDPI 2019-03-04 /pmc/articles/PMC6429493/ /pubmed/30836718 http://dx.doi.org/10.3390/molecules24050899 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Liskova, Alena Kubatka, Peter Samec, Marek Zubor, Pavol Mlyncek, Milos Bielik, Tibor Samuel, Samson Mathews Zulli, Anthony Kwon, Taeg Kyu Büsselberg, Dietrich Dietary Phytochemicals Targeting Cancer Stem Cells |
title | Dietary Phytochemicals Targeting Cancer Stem Cells |
title_full | Dietary Phytochemicals Targeting Cancer Stem Cells |
title_fullStr | Dietary Phytochemicals Targeting Cancer Stem Cells |
title_full_unstemmed | Dietary Phytochemicals Targeting Cancer Stem Cells |
title_short | Dietary Phytochemicals Targeting Cancer Stem Cells |
title_sort | dietary phytochemicals targeting cancer stem cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429493/ https://www.ncbi.nlm.nih.gov/pubmed/30836718 http://dx.doi.org/10.3390/molecules24050899 |
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