Lethal Influenza in Two Related Adults with Inherited GATA2 Deficiency

The pathogenesis of life-threatening influenza A virus (IAV) disease remains elusive, as infection is benign in most individuals. We studied two relatives who died from influenza. We Sanger sequenced GATA2 and evaluated the mutation by gene transfer, measured serum cytokine levels, and analyzed circ...

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Detalles Bibliográficos
Autores principales: Sologuren, Ithaisa, Martínez-Saavedra, María Teresa, Solé-Violán, Jordi, de Borges de Oliveira Jr, Edgar, Betancor, Eva, Casas, Inmaculada, Oleaga-Quintas, Carmen, Martínez-Gallo, Mónica, Zhang, Shen-Ying, Pestano, Jose, Colobran, Roger, Herrera-Ramos, Estefanía, Pérez, Carmen, López-Rodríguez, Marta, Ruiz-Hernández, José Juan, Franco, Nieves, Ferrer, José María, Bilbao, Cristina, Andújar-Sánchez, Miguel, Álvarez Fernández, Mercedes, Ciancanelli, Michael J., Rodríguez de Castro, Felipe, Casanova, Jean-Laurent, Bustamante, Jacinta, Rodríguez-Gallego, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429553/
https://www.ncbi.nlm.nih.gov/pubmed/29882021
http://dx.doi.org/10.1007/s10875-018-0512-0

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