Rh(III)-Catalyzed Annulation of Boc-Protected Benzamides with Diazo Compounds: Approach to Isocoumarins

A mild rhodium-catalyzed annulation of Boc-protected benzamides with diazo compounds via C−C/C−O bond formation has been explored. In the presence of [Cp*RhCl(2)](2), AgSbF(6) and Cs(2)CO(3), Boc-protected benzamides can be effectively annulated to yield isocoumarins in 0.5–2 h.

Detalles Bibliográficos
Autores principales: Dong, Guangyu, Li, Chunpu, Liu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429621/
https://www.ncbi.nlm.nih.gov/pubmed/30866510
http://dx.doi.org/10.3390/molecules24050937
Descripción
Sumario:A mild rhodium-catalyzed annulation of Boc-protected benzamides with diazo compounds via C−C/C−O bond formation has been explored. In the presence of [Cp*RhCl(2)](2), AgSbF(6) and Cs(2)CO(3), Boc-protected benzamides can be effectively annulated to yield isocoumarins in 0.5–2 h.

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