Cargando…

The gliadin-CFTR connection: new perspectives for the treatment of celiac disease

Familial loss-of-function mutations of the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) channel protein cause cystic fibrosis (CF), the most frequent inherited life-threatening disease in the Caucasian population. A recent study indicates that the gluten/gliadin-der...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maiuri, Luigi, Villella, Valeria R., Raia, Valeria, Kroemer, Guido
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Commentary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429699/ https://www.ncbi.nlm.nih.gov/pubmed/30898172 http://dx.doi.org/10.1186/s13052-019-0627-9

Ejemplares similares

Genistein antagonizes gliadin-induced CFTR malfunction in models of celiac disease
por: Esposito, Speranza, et al.
Publicado: (2019)

Cystic fibrosis transmembrane conductance regulator (CFTR) and autophagy: hereditary defects in cystic fibrosis versus gluten-mediated inhibition in celiac disease
por: Maiuri, Luigi, et al.
Publicado: (2019)

Defective proteostasis in celiac disease as a new therapeutic target
por: Maiuri, Luigi, et al.
Publicado: (2019)

Manipulating proteostasis to repair the F508del-CFTR defect in cystic fibrosis
por: Esposito, Speranza, et al.
Publicado: (2016)

Targeting the Intracellular Environment in Cystic Fibrosis: Restoring Autophagy as a Novel Strategy to Circumvent the CFTR Defect
por: Villella, Valeria Rachela, et al.
Publicado: (2013)

Cysteamine re-establishes the clearance of Pseudomonas aeruginosa by macrophages bearing the cystic fibrosis-relevant F508del-CFTR mutation
por: Ferrari, Eleonora, et al.
Publicado: (2017)

Strategies for the etiological therapy of cystic fibrosis
por: Maiuri, Luigi, et al.
Publicado: (2017)

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation
por: Stefano, Daniela De, et al.
Publicado: (2014)

Structural Perspective of Gliadin Peptides Active in Celiac Disease
por: Falcigno, Lucia, et al.
Publicado: (2020)

A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease
por: Villella, Valeria R, et al.
Publicado: (2018)

Pro-Inflammatory Nutrient: Focus on Gliadin and Celiac Disease
por: Barone, Maria Vittoria, et al.
Publicado: (2022)

Probiotics Supplements Reduce ER Stress and Gut Inflammation Associated with Gliadin Intake in a Mouse Model of Gluten Sensitivity
por: Ferrari, Eleonora, et al.
Publicado: (2021)

The Multifaceted Roles of MicroRNAs in Cystic Fibrosis
por: De Palma, Fatima Domenica Elisa, et al.
Publicado: (2020)

Intestinal Epithelium Modulates Macrophage Response to Gliadin in Celiac Disease
por: Serena, Gloria, et al.
Publicado: (2019)

Application of Deamidated Gliadin Antibodies in the Follow-Up of Treated Celiac Disease
por: de Chaisemartin, Luc, et al.
Publicado: (2015)

The α-Gliadins in Bread Wheat: Effect of Nitrogen Treatment on the Expression of the Major Celiac Disease Immunogenic Complex in Two RNAi Low-Gliadin Lines
por: Sánchez-León, Susana, et al.
Publicado: (2021)

Celiac disease & type 1 diabetes mellitus: Connections & implications
por: Vyas, Varuna, et al.
Publicado: (2017)

Exploring T Cell Reactivity to Gliadin in Young Children with Newly Diagnosed Celiac Disease
por: Liu, Edwin, et al.
Publicado: (2014)

Autophagy suppresses the pathogenic immune response to dietary antigens in cystic fibrosis
por: Villella, Valeria R., et al.
Publicado: (2019)

Autophagy delays progression of the two most frequent human monogenetic lethal diseases: cystic fibrosis and Wilson disease
por: Maiuri, Luigi, et al.
Publicado: (2018)

Effect of Gliadin on Permeability of Intestinal Biopsy Explants from Celiac Disease Patients and Patients with Non-Celiac Gluten Sensitivity
por: Hollon, Justin, et al.
Publicado: (2015)

Trehalose Modulates Autophagy Process to Counteract Gliadin Cytotoxicity in an In Vitro Celiac Disease Model
por: Manai, Federico, et al.
Publicado: (2019)

A Universal Approach to Eliminate Antigenic Properties of Alpha-Gliadin Peptides in Celiac Disease
por: Mitea, Cristina, et al.
Publicado: (2010)

Genome-wide analysis of complex wheat gliadins, the dominant carriers of celiac disease epitopes
por: Wang, Da-Wei, et al.
Publicado: (2017)

Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols
por: Van Buiten, Charlene B., et al.
Publicado: (2021)

New structural insights into the gating movements of CFTR
por: Puljung, Michael C.
Publicado: (2015)

A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR
por: Tosco, A, et al.
Publicado: (2016)

Constitutive alterations in vesicular trafficking increase the sensitivity of cells from celiac disease patients to gliadin
por: Lania, Giuliana, et al.
Publicado: (2019)

Correction: A Universal Approach to Eliminate Antigenic Properties of Alpha-Gliadin Peptides in Celiac Disease
por: Mitea, Cristina, et al.
Publicado: (2012)

Gliadin-Mediated Proliferation and Innate Immune Activation in Celiac Disease Are Due to Alterations in Vesicular Trafficking
por: Barone, M. Vittoria, et al.
Publicado: (2011)

Celiac Disease Defined by Over-Sensitivity to Gliadin Activation and Superior Antigen Presentation of Dendritic Cells
por: Hudec, Michael, et al.
Publicado: (2021)

Celiac Immunogenic Potential of α-Gliadin Epitope Variants from Triticum and Aegilops Species
por: Ruiz-Carnicer, Ángela, et al.
Publicado: (2019)

Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease
por: Matysiak-Budnik, Tamara, et al.
Publicado: (2008)

Identification of wheat proteins involved in active stage of celiac disease: are gamma gliadins the major disease-specific antigens?
por: Srinivasan, Bharani, et al.
Publicado: (2011)

Clinical spectrum of Celiac disease from a cardiology perspective
por: Myrmel, Gard M. S., et al.
Publicado: (2022)

S737F is a new CFTR mutation typical of patients originally from the Tuscany region in Italy
por: Terlizzi, Vito, et al.
Publicado: (2018)

Gamma-gliadin specific celiac disease antibodies recognize p31-43 and p57-68 alpha gliadin peptides in deamidation related manner as a result of cross-reaction
por: Diós, Ádám, et al.
Publicado: (2021)

Evaluation of autophagy inducers in epithelial cells carrying the ΔF508 mutation of the cystic fibrosis transmembrane conductance regulator CFTR
por: Zhang, Shaoyi, et al.
Publicado: (2018)

Author Correction: Constitutive alterations in vesicular trafficking increase the sensitivity of cells from celiac disease patients to gliadin
por: Lania, Giuliana, et al.
Publicado: (2020)

Effect of gluten free diet on immune response to gliadin in patients with non-celiac gluten sensitivity
por: Caio, Giacomo, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_sdv4p8qsr6s2foa6fh8e31rn4g