Cargando…

Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells

BACKGROUND: Monoclonal antibodies targeting programmed death-1 receptor (PD-1) and its ligand (PD-L1) have been developed to treat cancers including lung cancer. In this study, we aimed to investigate whether lycopene could promote the effect of anti-PD-1 treatment on lung cancer. METHODS: Tumor for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Xiufeng, Wu, Hui, Zhao, Wei, Ding, Xiao, You, Qian, Zhu, Feng, Qian, Meifang, Yu, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429703/ https://www.ncbi.nlm.nih.gov/pubmed/30948928 http://dx.doi.org/10.1186/s12935-019-0789-y

Ejemplares similares

Effect of lycopene on cell viability and cell cycle progression in human cancer cell lines
por: Teodoro, Anderson Junger, et al.
Publicado: (2012)

Adipocytes promote tumor progression and induce PD-L1 expression via TNF-α/IL-6 signaling
por: Li, Zhi, et al.
Publicado: (2020)

KRAS acting through ERK signaling stabilizes PD-L1 via inhibiting autophagy pathway in intrahepatic cholangiocarcinoma
por: Gao, Zheng, et al.
Publicado: (2022)

Serum-derived exosomes promote CD8+ T cells to overexpress PD-1, affecting the prognosis of hypopharyngeal carcinoma
por: Gao, Qian, et al.
Publicado: (2021)

SCD1 is required for EGFR-targeting cancer therapy of lung cancer via re-activation of EGFR/PI3K/AKT signals
por: She, Kelin, et al.
Publicado: (2019)

Suppressive effects of plumbagin on the growth of human bladder cancer cells via PI3K/AKT/mTOR signaling pathways and EMT
por: Zhang, Renjie, et al.
Publicado: (2020)

The prognostic significance of PD-L1 and PD-1 expression in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis
por: Huang, Zi-Lu, et al.
Publicado: (2019)

CLDN2 inhibits the metastasis of osteosarcoma cells via down-regulating the afadin/ERK signaling pathway
por: Zhang, Xiaowei, et al.
Publicado: (2018)

NCAPG promotes the progression of lung adenocarcinoma via the TGF-β signaling pathway
por: Wu, Yun, et al.
Publicado: (2021)

Analysis of PD-1 related immune transcriptional profile in different cancer types
por: Shang, Jun, et al.
Publicado: (2018)

Role of microRNA-33a in regulating the expression of PD-1 in lung adenocarcinoma
por: Boldrini, Laura, et al.
Publicado: (2017)

Metformin exerts anti-AR-negative prostate cancer activity via AMPK/autophagy signaling pathway
por: Chen, Chunyang, et al.
Publicado: (2021)

CD44, a marker of cancer stem cells, is positively correlated with PD-L1 expression and immune cells infiltration in lung adenocarcinoma
por: Zhang, Chenyue, et al.
Publicado: (2020)

C-Phycocyanin exerts anti-cancer effects via the MAPK signaling pathway in MDA-MB-231 cells
por: Jiang, Liangqian, et al.
Publicado: (2018)

Down-regulation of TRIB3 inhibits the progression of ovarian cancer via MEK/ERK signaling pathway
por: Wang, Shuang, et al.
Publicado: (2020)

Apolipoprotein C1 stimulates the malignant process of renal cell carcinoma via the Wnt3a signaling
por: Jiang, Hao, et al.
Publicado: (2021)

HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway
por: Wang, Xinyu, et al.
Publicado: (2020)

Identification and validation of stromal-tumor microenvironment-based subtypes tightly associated with PD-1/PD-L1 immunotherapy and outcomes in patients with gastric cancer
por: Ren, Qianqian, et al.
Publicado: (2020)

Protein kinase ERK contributes to differential responsiveness of human myeloma cell lines to IFNα
por: Song, Lun, et al.
Publicado: (2002)

IFNγ/PD-L1 Signaling Improves the Responsiveness of Anti-PD-1 Therapy in Colorectal Cancer: An in vitro Study
por: Yuan, Wenli, et al.
Publicado: (2021)

Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells
por: Fong, Yao, et al.
Publicado: (2017)

Genomic correlates of programmed cell death ligand 1 (PD-L1) expression in Chinese lung adenocarcinoma patients
por: Li, Kang, et al.
Publicado: (2022)

The cholesterol esterification inhibitor avasimibe suppresses tumour proliferation and metastasis via the E2F-1 signalling pathway in prostate cancer
por: Xiong, Kangping, et al.
Publicado: (2021)

TRIM27 promotes the development of esophagus cancer via regulating PTEN/AKT signaling pathway
por: Ma, Liang, et al.
Publicado: (2019)

ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma
por: Liu, Yalu, et al.
Publicado: (2019)

SALL4 promotes gastric cancer progression via hexokinase II mediated glycolysis
por: Shao, Meng, et al.
Publicado: (2020)

PD-1 and PD-L1 correlated gene expression profiles and their association with clinical outcomes of breast cancer
por: Jiang, Cui, et al.
Publicado: (2019)

LncRNA HCG11 promotes proliferation and migration in gastric cancer via targeting miR-1276/CTNNB1 and activating Wnt signaling pathway
por: Zhang, Hua, et al.
Publicado: (2019)

MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer
por: Alburquerque-Bejar, Juan J., et al.
Publicado: (2023)

AGI-134: a fully synthetic α-Gal glycolipid that converts tumors into in situ autologous vaccines, induces anti-tumor immunity and is synergistic with an anti-PD-1 antibody in mouse melanoma models
por: Shaw, Stephen M., et al.
Publicado: (2019)

SKA1 promotes malignant phenotype and progression of glioma via multiple signaling pathways
por: Wang, Xizhao, et al.
Publicado: (2019)

Kinesin superfamily protein 21B acts as an oncogene in non-small cell lung cancer
por: Sun, Zhi-Gang, et al.
Publicado: (2020)

ADAM10 is involved in the oncogenic process and chemo-resistance of triple-negative breast cancer via regulating Notch1 signaling pathway, CD44 and PrPc
por: Cheng, Yuanyuan, et al.
Publicado: (2021)

miR-502-5p affects gastric cancer progression by targeting PD-L1
por: You, Wendao, et al.
Publicado: (2020)

Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcripts
por: Crosby, Lynn M, et al.
Publicado: (2010)

Novaferon, a novel recombinant protein produced by DNA-shuffling of IFN-α, shows antitumor effect in vitro and in vivo
por: Li, Meng, et al.
Publicado: (2014)

Oridonin inhibits pancreatic cancer cell migration and epithelial-mesenchymal transition by suppressing Wnt/β-catenin signaling pathway
por: Liu, Qian-Qian, et al.
Publicado: (2016)

NEIL3 may act as a potential prognostic biomarker for lung adenocarcinoma
por: Zhao, Cui, et al.
Publicado: (2021)

EFTUD2 gene deficiency disrupts osteoblast maturation and inhibits chondrocyte differentiation via activation of the p53 signaling pathway
por: Wu, Jing, et al.
Publicado: (2019)

NEDD4L-induced ubiquitination mediating UBE2T degradation inhibits progression of lung adenocarcinoma via PI3K-AKT signaling
por: Chen, Yongbing, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_88ke1pl9hd12vbkq3pua2tutme