Cargando…

Discovery of a natural small-molecule compound that suppresses tumor EMT, stemness and metastasis by inhibiting TGFβ/BMP signaling in triple-negative breast cancer

BACKGROUND: The transforming growth factor β (TGFβ) and bone morphogenetic protein (BMP) signaling pathways are both constitutively activated in triple-negative breast cancer (TNBC). We are interested in isolating the naturally-derived small-molecule inhibitor that could simultaneously targeting TGF...

Descripción completa

Detalles Bibliográficos
Autores principales:	Di, Lei, Liu, Li-Juan, Yan, Yong-Ming, Fu, Rong, Li, Yi, Xu, Ying, Cheng, Yong-Xian, Wu, Zhao-Qiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429712/ https://www.ncbi.nlm.nih.gov/pubmed/30898152 http://dx.doi.org/10.1186/s13046-019-1130-2

Ejemplares similares

ICAM1 promotes bone metastasis via integrin‐mediated TGF‐β/EMT signaling in triple‐negative breast cancer
por: Chen, Mingcang, et al.
Publicado: (2022)

Pirfenidone suppressed triple‐negative breast cancer metastasis by inhibiting the activity of the TGF‐β/SMAD pathway
por: Luo, Daiqin, et al.
Publicado: (2023)

TMEM158 Regulates the Canonical and Non-Canonical Pathways of TGF-β to Mediate EMT in Triple-Negative Breast Cancer
por: Tong, Jiaci, et al.
Publicado: (2022)

The role of EMT-related lncRNA in the process of triple-negative breast cancer metastasis
por: Zhang, Haomeng, et al.
Publicado: (2021)

Bufotalin Suppresses Proliferation and Metastasis of Triple-Negative Breast Cancer Cells by Promoting Apoptosis and Inhibiting the STAT3/EMT Axis
por: Park, So Jin, et al.
Publicado: (2023)

Up-Regulation of RFC3 Promotes Triple Negative Breast Cancer Metastasis and is Associated With Poor Prognosis Via EMT
por: He, Zhen-Yu, et al.
Publicado: (2016)

miR-425 suppresses EMT and the development of TNBC (triple-negative breast cancer) by targeting the TGF-β 1/SMAD 3 signaling pathway
por: Liu, Yingping, et al.
Publicado: (2018)

DGKZ promotes TGFβ signaling pathway and metastasis in triple-negative breast cancer by suppressing lipid raft-dependent endocytosis of TGFβR2
por: Zhao, Yuanyuan, et al.
Publicado: (2022)

SRGN-TGFβ2 regulatory loop confers invasion and metastasis in triple-negative breast cancer
por: Zhang, Z, et al.
Publicado: (2017)

Inhibition of DOT1L by Half-Selenopsammaplin A Analogs Suppresses Tumor Growth and EMT-Mediated Metastasis in Triple-Negative Breast Cancer
por: Byun, Woong Sub, et al.
Publicado: (2020)

Lovastatin Inhibits EMT and Metastasis of Triple-Negative Breast Cancer Stem Cells Through Dysregulation of Cytoskeleton-Associated Proteins
por: Zheng, Chanjuan, et al.
Publicado: (2021)

An EMT-Related Gene Signature to Predict the Prognosis of Triple-Negative Breast Cancer
por: Zhang, Bo, et al.
Publicado: (2023)

The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors
por: Mock, Kerstin, et al.
Publicado: (2015)

BMP-4 and BMP-7 Inhibit EMT in a Model of Anterior Subcapsular Cataract in Part by Regulating the Notch Signaling Pathway
por: Jiang, Fanying, et al.
Publicado: (2023)

PTBP3 mediates TGF-β-induced EMT and metastasis of lung adenocarcinoma
por: Dong, Chenglai, et al.
Publicado: (2022)

Quaking 5 suppresses TGF‐β‐induced EMT and cell invasion in lung adenocarcinoma
por: Wang, Shengjie, et al.
Publicado: (2021)

Fuling Granule, a Traditional Chinese Medicine Compound, Suppresses Cell Proliferation and TGFβ-Induced EMT in Ovarian Cancer
por: Tao, Fangfang, et al.
Publicado: (2016)

Inhibition of BMP Signaling Suppresses Metastasis in Mammary Cancer
por: Owens, P., et al.
Publicado: (2014)

The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer
por: Fatima, Iram, et al.
Publicado: (2017)

LncRNA ANCR down-regulation promotes TGF-β-induced EMT and metastasis in breast cancer
por: Li, Zhongwei, et al.
Publicado: (2017)

New Insights into the Implication of Epigenetic Alterations in the EMT of Triple Negative Breast Cancer
por: Khaled, Noura, et al.
Publicado: (2019)

Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo
por: Jeon, Hyein, et al.
Publicado: (2016)

Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer
por: Humphries, Brock A., et al.
Publicado: (2020)

TGF-β in developmental and fibrogenic EMTs
por: Lee, Jun Ho, et al.
Publicado: (2022)

Small-Molecule-Mediated Suppression of BMP Signaling by Selective Inhibition of BMP1-Dependent Chordin Cleavage
por: Mizoguchi, Takamasa, et al.
Publicado: (2023)

MicroRNA-590 is an EMT-suppressive microRNA involved in the TGFβ signaling pathway
por: LIU, TIANMING, et al.
Publicado: (2015)

Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-β/SMAD signaling
por: Jiang, Hong-Lin, et al.
Publicado: (2015)

Immune Checkpoint and EMT-Related Molecules in Circulating Tumor Cells (CTCs) from Triple Negative Breast Cancer Patients and Their Clinical Impact
por: Vardas, Vasileios, et al.
Publicado: (2023)

Agrin Binds BMP2, BMP4 and TGFβ1
por: Bányai, László, et al.
Publicado: (2010)

Correction: The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer
por: Fatima, Iram, et al.
Publicado: (2018)

Comparison of Clinicopathological Features and Prognosis in Triple-Negative and Non-Triple Negative Breast Cancer
por: Qiu, Jingdan, et al.
Publicado: (2016)

RNA N(6)-methyladenosine reader YTHDC1 is essential for TGF-beta-mediated metastasis of triple negative breast cancer
por: Tan, Brandon, et al.
Publicado: (2022)

The miR-124-3p/Neuropilin-1 Axis Contributes to the Proliferation and Metastasis of Triple-Negative Breast Cancer Cells and Co-Activates the TGF-β Pathway
por: Zhang, Jiayang, et al.
Publicado: (2021)

microRNA-214-3p Suppresses Ankylosing Spondylitis Fibroblast Osteogenesis via BMP–TGFβ Axis and BMP2
por: Ding, Lixiang, et al.
Publicado: (2021)

Upregulation Of miR-153 Inhibits Triple-Negative Breast Cancer Progression By Targeting ZEB2-Mediated EMT And Contributes To Better Prognosis
por: Shi, Dongliang, et al.
Publicado: (2019)

Cystine addiction of triple negative breast cancer associated with EMT augmented death signaling
por: Tang, Xiaohu, et al.
Publicado: (2016)

RAGE inhibitor TTP488 (Azeliragon) suppresses metastasis in triple-negative breast cancer
por: Magna, Melinda, et al.
Publicado: (2023)

TGF-β induced reprogramming and drug resistance in triple-negative breast cells
por: Wu, Guoyu, et al.
Publicado: (2022)

EMT and tumor metastasis
por: Heerboth, Sarah, et al.
Publicado: (2015)

Angiotensin Inhibition, TGF-β and EMT in Cancer
por: Pallasch, Fabian Bernhard, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_48rom933095i3cgag5htfi8e64