Cargando…

Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers

BACKGROUND: The Centiloid scale has been developed to standardize measurements of amyloid PET imaging. Reference cut-off values of this continuous measurement enable the consistent operationalization of decision-making for multicentre research studies and clinical trials. In this study, we aimed at...

Descripción completa

Detalles Bibliográficos
Autores principales:	Salvadó, Gemma, Molinuevo, José Luis, Brugulat-Serrat, Anna, Falcon, Carles, Grau-Rivera, Oriol, Suárez-Calvet, Marc, Pavia, Javier, Niñerola-Baizán, Aida, Perissinotti, Andrés, Lomeña, Francisco, Minguillon, Carolina, Fauria, Karine, Zetterberg, Henrik, Blennow, Kaj, Gispert, Juan Domingo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429814/ https://www.ncbi.nlm.nih.gov/pubmed/30902090 http://dx.doi.org/10.1186/s13195-019-0478-z

Ejemplares similares

Brain alterations in the early Alzheimer’s continuum with amyloid-β, tau, glial and neurodegeneration CSF markers
por: Salvadó, Gemma, et al.
Publicado: (2022)

Cognitively unimpaired individuals with a low burden of Aβ pathology have a distinct CSF biomarker profile
por: Milà-Alomà, Marta, et al.
Publicado: (2021)

Cerebral amyloid‐β load is associated with neurodegeneration and gliosis: Mediation by p‐tau and interactions with risk factors early in the Alzheimer's continuum
por: Salvadó, Gemma, et al.
Publicado: (2021)

CSF Synaptic Biomarkers in the Preclinical Stage of Alzheimer Disease and Their Association With MRI and PET: A Cross-sectional Study
por: Milà-Alomà, Marta, et al.
Publicado: (2021)

Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer’s continuum
por: Salvadó, Gemma, et al.
Publicado: (2022)

APOE-ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals
por: Brugulat-Serrat, Anna, et al.
Publicado: (2023)

Spatial patterns of white matter hyperintensities associated with Alzheimer’s disease risk factors in a cognitively healthy middle-aged cohort
por: Salvadó, Gemma, et al.
Publicado: (2019)

White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants
por: Brugulat‐Serrat, Anna, et al.
Publicado: (2019)

Reference Data for Attentional, Executive, Linguistic, and Visual Processing Tests Obtained from Cognitively Healthy Individuals with Normal Alzheimer’s Disease Cerebrospinal Fluid Biomarker Levels
por: López-Martos, David, et al.
Publicado: (2023)

Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults
por: Grau-Rivera, Oriol, et al.
Publicado: (2020)

Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals
por: Brugulat-Serrat, Anna, et al.
Publicado: (2019)

APOE-ε4 Shapes the Cerebral Organization in Cognitively Intact Individuals as Reflected by Structural Gray Matter Networks
por: Cacciaglia, Raffaele, et al.
Publicado: (2020)

Association of weight change with cerebrospinal fluid biomarkers and amyloid positron emission tomography in preclinical Alzheimer’s disease
por: Grau-Rivera, Oriol, et al.
Publicado: (2021)

Episodic memory and executive functions in cognitively healthy individuals display distinct neuroanatomical correlates which are differentially modulated by aging
por: Cacciaglia, Raffaele, et al.
Publicado: (2018)

Quantitative informant‐ and self‐reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4
por: Sánchez‐Benavides, Gonzalo, et al.
Publicado: (2020)

Enhancing the Sensitivity of Memory Tests: Reference Data for the Free and Cued Selective Reminding Test and the Logical Memory Task from Cognitively Healthy Subjects with Normal Alzheimer’s Disease Cerebrospinal Fluid Biomarker Levels
por: Brugulat-Serrat, Anna, et al.
Publicado: (2021)

Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease: a cross-sectional analysis from the ALFA (Alzheimer and Families) project
por: Brugulat-Serrat, Anna, et al.
Publicado: (2017)

Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects
por: Operto, Grégory, et al.
Publicado: (2019)

Genotypic effects of APOE-ε4 on resting-state connectivity in cognitively intact individuals support functional brain compensation
por: Cacciaglia, Raffaele, et al.
Publicado: (2022)

APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals
por: Cacciaglia, Raffaele, et al.
Publicado: (2019)

Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation
por: Skouras, Stavros, et al.
Publicado: (2020)

Subjective cognitive decline and anxious/depressive symptoms during the COVID-19 pandemic: what is the role of stress perception, stress resilience, and β-amyloid?
por: Akinci, Muge, et al.
Publicado: (2022)

Brain and cognitive correlates of subjective cognitive decline-plus features in a population-based cohort
por: Sánchez-Benavides, Gonzalo, et al.
Publicado: (2018)

White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes
por: Operto, Grégory, et al.
Publicado: (2018)

Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer’s continuum
por: Vilor-Tejedor, Natalia, et al.
Publicado: (2021)

CSF glial biomarkers YKL40 and sTREM2 are associated with longitudinal volume and diffusivity changes in cognitively unimpaired individuals
por: Falcon, Carles, et al.
Publicado: (2019)

Distinct Cognitive and Brain Morphological Features in Healthy Subjects Unaware of Informant-Reported Cognitive Decline
por: Sánchez-Benavides, Gonzalo, et al.
Publicado: (2018)

Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum
por: Milà‐Alomà, Marta, et al.
Publicado: (2020)

Age, sex and APOE-ε4 modify the balance between soluble and fibrillar β-amyloid in non-demented individuals: topographical patterns across two independent cohorts
por: Cacciaglia, Raffaele, et al.
Publicado: (2022)

Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer’s continuum when only subtle changes in Aβ pathology are detected
por: Suárez‐Calvet, Marc, et al.
Publicado: (2020)

DHA intake relates to better cerebrovascular and neurodegeneration neuroimaging phenotypes in middle-aged adults at increased genetic risk of Alzheimer disease
por: Sala-Vila, Aleix, et al.
Publicado: (2021)

Prepandemic Alzheimer Disease Biomarkers and Anxious-Depressive Symptoms During the COVID-19 Confinement in Cognitively Unimpaired Adults
por: Akinci, Muge, et al.
Publicado: (2022)

Lessons from Multicenter Studies on CSF Biomarkers for Alzheimer's Disease
por: Mattsson, Niklas, et al.
Publicado: (2010)

Exploring cognitive and biological correlates of sleep quality and their potential links with Alzheimer’s disease (ALFASleep project): protocol for an observational study
por: Fauria, Karine, et al.
Publicado: (2022)

PISCOM: a new procedure for epilepsy combining ictal SPECT and interictal PET
por: Perissinotti, Andrés, et al.
Publicado: (2018)

Structural Connectivity Alterations Along the Alzheimer’s Disease Continuum: Reproducibility Across Two Independent Samples and Correlation with Cerebrospinal Fluid Amyloid-β and Tau
por: Tucholka, Alan, et al.
Publicado: (2018)

Effects of pre‐analytical procedures on blood biomarkers for Alzheimer's pathophysiology, glial activation, and neurodegeneration
por: Ashton, Nicholas J., et al.
Publicado: (2021)

A universal neocortical mask for Centiloid quantification
por: Bourgeat, Pierrick, et al.
Publicado: (2023)

Longitudinal structural cerebral changes related to core CSF biomarkers in preclinical Alzheimer's disease: A study of two independent datasets
por: Falcon, Carles, et al.
Publicado: (2018)

Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer’s disease and neurodegeneration stratified by sex
por: Cumplido-Mayoral, Irene, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_1eu5hrh9i0m410m172l2pf2eeg