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Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease

BACKGROUND: Synaptic damage precedes neuron death in Alzheimer’s disease (AD). Neurexins, NRXN1, NRXN2, and NRXN3, are presynaptic adhesion molecules that specify neuron synapses and regulate neurotransmitter release. Neurexins and postsynaptic neuroligins interact with amyloid beta oligomer (AβO) d...

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Detalles Bibliográficos
Autores principales:	Hishimoto, Akitoyo, Pletnikova, Olga, Lang, Doyle Lu, Troncoso, Juan C., Egan, Josephine M., Liu, Qing-Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429815/ https://www.ncbi.nlm.nih.gov/pubmed/30902061 http://dx.doi.org/10.1186/s13195-019-0475-2

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