Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt

The Ser/Thr kinase Akt (Protein Kinase B/PKB) is a master switch in cellular signal transduction pathways. Its downstream signaling influences cell proliferation, cell growth, and apoptosis, rendering Akt a prominent drug target. The unique activation mechanism of Akt involves a change of the relati...

Descripción completa

Detalles Bibliográficos
Autores principales: Uhlenbrock, Niklas, Smith, Steven, Weisner, Jörn, Landel, Ina, Lindemann, Marius, Le, Thien Anh, Hardick, Julia, Gontla, Rajesh, Scheinpflug, Rebekka, Czodrowski, Paul, Janning, Petra, Depta, Laura, Quambusch, Lena, Müller, Matthias P., Engels, Bernd, Rauh, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430017/
https://www.ncbi.nlm.nih.gov/pubmed/30996949
http://dx.doi.org/10.1039/c8sc05212c

Ejemplares similares

Ejemplares similares