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The mechanism of PI3Kα activation at the atomic level

PI3K lipid kinases phosphorylate PIP(2) to PIP(3) in the PI3K/Akt/mTOR pathway to regulate cellular processes. They are frequently mutated in cancer. Here we determine the PI3Kα activation mechanism at the atomic level. Unlike protein kinases where the substrate abuts the ATP, crystal structures ind...

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Detalles Bibliográficos
Autores principales:	Zhang, Mingzhen, Jang, Hyunbum, Nussinov, Ruth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430085/ https://www.ncbi.nlm.nih.gov/pubmed/30996962 http://dx.doi.org/10.1039/c8sc04498h

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