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Increased risk of thyroid disease in patients with Sjogren's syndrome: a systematic review and meta-analysis

BACKGROUND: Sjogren’s syndrome (SS) is a chronic autoimmune epithelitis characterized by disruption of epithelial cells, ensuing lymphoplasmocytic infiltration of exocrine glands, and subsequent dryness of the mouth and eyes. Individuals with SS are more likely to have the thyroid disease. However,...

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Autores principales: Sun, Xin, Lu, Li, Li, Yanbin, Yang, Rong, Shan, Ling, Wang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430100/
https://www.ncbi.nlm.nih.gov/pubmed/30918763
http://dx.doi.org/10.7717/peerj.6737
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author Sun, Xin
Lu, Li
Li, Yanbin
Yang, Rong
Shan, Ling
Wang, Yang
author_facet Sun, Xin
Lu, Li
Li, Yanbin
Yang, Rong
Shan, Ling
Wang, Yang
author_sort Sun, Xin
collection PubMed
description BACKGROUND: Sjogren’s syndrome (SS) is a chronic autoimmune epithelitis characterized by disruption of epithelial cells, ensuing lymphoplasmocytic infiltration of exocrine glands, and subsequent dryness of the mouth and eyes. Individuals with SS are more likely to have the thyroid disease. However, this association remains controversial. This meta-analysis aimed to evaluate the risk of thyroid disease in patients with SS. METHODS: We performed this systematic review by searching both English and Chinese literature databases. Random- or fixed-effects models were used to summarize the association between thyroid disease and SS. The results were subjected to meta-analysis with odds ratios (ORs) and corresponding 95% confidence intervals (CIs). RESULTS: The eight articles in this meta-analysis included 988 SS cases and 2,884 controls. Overall, the risk of thyroid disease in patients with SS was significantly increased compared with controls (OR, 3.29; 95% CI [2.08–5.21]). The risk of autoimmune thyroid disease (AITD) and non-AITD were also higher in patients with SS than in controls (OR, 3.48; 95% CI [1.59–7.63]; and OR, 2.90; 95% CI [1.51–5.57], respectively). CONCLUSIONS: To the best of our knowledge, this systematic review is the first to demonstrate that the risk of thyroid disease was increased in SS compared to controls, suggesting that SS patients should be screened for thyroid disease.
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spelling pubmed-64301002019-03-27 Increased risk of thyroid disease in patients with Sjogren's syndrome: a systematic review and meta-analysis Sun, Xin Lu, Li Li, Yanbin Yang, Rong Shan, Ling Wang, Yang PeerJ Diabetes and Endocrinology BACKGROUND: Sjogren’s syndrome (SS) is a chronic autoimmune epithelitis characterized by disruption of epithelial cells, ensuing lymphoplasmocytic infiltration of exocrine glands, and subsequent dryness of the mouth and eyes. Individuals with SS are more likely to have the thyroid disease. However, this association remains controversial. This meta-analysis aimed to evaluate the risk of thyroid disease in patients with SS. METHODS: We performed this systematic review by searching both English and Chinese literature databases. Random- or fixed-effects models were used to summarize the association between thyroid disease and SS. The results were subjected to meta-analysis with odds ratios (ORs) and corresponding 95% confidence intervals (CIs). RESULTS: The eight articles in this meta-analysis included 988 SS cases and 2,884 controls. Overall, the risk of thyroid disease in patients with SS was significantly increased compared with controls (OR, 3.29; 95% CI [2.08–5.21]). The risk of autoimmune thyroid disease (AITD) and non-AITD were also higher in patients with SS than in controls (OR, 3.48; 95% CI [1.59–7.63]; and OR, 2.90; 95% CI [1.51–5.57], respectively). CONCLUSIONS: To the best of our knowledge, this systematic review is the first to demonstrate that the risk of thyroid disease was increased in SS compared to controls, suggesting that SS patients should be screened for thyroid disease. PeerJ Inc. 2019-03-19 /pmc/articles/PMC6430100/ /pubmed/30918763 http://dx.doi.org/10.7717/peerj.6737 Text en © 2019 Sun et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Diabetes and Endocrinology
Sun, Xin
Lu, Li
Li, Yanbin
Yang, Rong
Shan, Ling
Wang, Yang
Increased risk of thyroid disease in patients with Sjogren's syndrome: a systematic review and meta-analysis
title Increased risk of thyroid disease in patients with Sjogren's syndrome: a systematic review and meta-analysis
title_full Increased risk of thyroid disease in patients with Sjogren's syndrome: a systematic review and meta-analysis
title_fullStr Increased risk of thyroid disease in patients with Sjogren's syndrome: a systematic review and meta-analysis
title_full_unstemmed Increased risk of thyroid disease in patients with Sjogren's syndrome: a systematic review and meta-analysis
title_short Increased risk of thyroid disease in patients with Sjogren's syndrome: a systematic review and meta-analysis
title_sort increased risk of thyroid disease in patients with sjogren's syndrome: a systematic review and meta-analysis
topic Diabetes and Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430100/
https://www.ncbi.nlm.nih.gov/pubmed/30918763
http://dx.doi.org/10.7717/peerj.6737
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