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Sleep and Attention in Alzheimer’s Disease

Individuals with Alzheimer’s disease (AD) present with a wide variety of symptoms, including sleep disruption and sleep disorders. Conversely, disordered sleep has been associated with an increased risk of developing AD. Both conditions individually have adverse effects on attention, which can be fu...

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Detalles Bibliográficos
Autores principales: Hennawy, Mirna, Sabovich, Solomon, Liu, Celina S., Herrmann, Nathan, Lanctôt, Krista L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: YJBM 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430169/
https://www.ncbi.nlm.nih.gov/pubmed/30923473
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author Hennawy, Mirna
Sabovich, Solomon
Liu, Celina S.
Herrmann, Nathan
Lanctôt, Krista L.
author_facet Hennawy, Mirna
Sabovich, Solomon
Liu, Celina S.
Herrmann, Nathan
Lanctôt, Krista L.
author_sort Hennawy, Mirna
collection PubMed
description Individuals with Alzheimer’s disease (AD) present with a wide variety of symptoms, including sleep disruption and sleep disorders. Conversely, disordered sleep has been associated with an increased risk of developing AD. Both conditions individually have adverse effects on attention, which can be further divided into selective, sustained, divided, and alternating attention. The neural mechanisms underpinning sleep problems in AD involve the disruption of the circadian system. This review comprehensively discusses the types of attention impairments, the relationship between AD pathology and sleep disruption, and the effect of sleep issues on attention in AD. Recommendations for future research include addressing the lack of consistency among study designs and outcomes, and the need to continue exploring the biology of sleep and attention in AD.
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spelling pubmed-64301692019-03-28 Sleep and Attention in Alzheimer’s Disease Hennawy, Mirna Sabovich, Solomon Liu, Celina S. Herrmann, Nathan Lanctôt, Krista L. Yale J Biol Med Review Individuals with Alzheimer’s disease (AD) present with a wide variety of symptoms, including sleep disruption and sleep disorders. Conversely, disordered sleep has been associated with an increased risk of developing AD. Both conditions individually have adverse effects on attention, which can be further divided into selective, sustained, divided, and alternating attention. The neural mechanisms underpinning sleep problems in AD involve the disruption of the circadian system. This review comprehensively discusses the types of attention impairments, the relationship between AD pathology and sleep disruption, and the effect of sleep issues on attention in AD. Recommendations for future research include addressing the lack of consistency among study designs and outcomes, and the need to continue exploring the biology of sleep and attention in AD. YJBM 2019-03-25 /pmc/articles/PMC6430169/ /pubmed/30923473 Text en Copyright ©2019, Yale Journal of Biology and Medicine https://creativecommons.org/licenses/by-nc/3.0/ This is an open access article distributed under the terms of the Creative Commons CC BY-NC license, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use the material for commercial purposes.
spellingShingle Review
Hennawy, Mirna
Sabovich, Solomon
Liu, Celina S.
Herrmann, Nathan
Lanctôt, Krista L.
Sleep and Attention in Alzheimer’s Disease
title Sleep and Attention in Alzheimer’s Disease
title_full Sleep and Attention in Alzheimer’s Disease
title_fullStr Sleep and Attention in Alzheimer’s Disease
title_full_unstemmed Sleep and Attention in Alzheimer’s Disease
title_short Sleep and Attention in Alzheimer’s Disease
title_sort sleep and attention in alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430169/
https://www.ncbi.nlm.nih.gov/pubmed/30923473
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