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Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430207/ https://www.ncbi.nlm.nih.gov/pubmed/30482948 http://dx.doi.org/10.1038/s41593-018-0275-1 |
| _version_ | 1783405741395148800 |
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| author | Walters, Raymond K. Polimanti, Renato Johnson, Emma C. McClintick, Jeanette N. Adams, Mark J. Adkins, Amy E. Aliev, Fazil Bacanu, Silviu-Alin Batzler, Anthony Bertelsen, Sarah Biernacka, Joanna M. Bigdeli, Tim B. Chen, Li-Shiun Clarke, Toni-Kim Chou, Yi-Ling Degenhardt, Franziska Docherty, Anna R. Edwards, Alexis C. Fontanillas, Pierre Foo, Jerome C. Fox, Louis Frank, Josef Giegling, Ina Gordon, Scott Hack, Laura M. Hartmann, Annette M. Hartz, Sarah M. Heilmann-Heimbach, Stefanie Herms, Stefan Hodgkinson, Colin Hoffmann, Per Hottenga, Jouke Jan Kennedy, Martin A. Alanne-Kinnunen, Mervi Konte, Bettina Lahti, Jari Lahti-Pulkkinen, Marius Lai, Dongbing Ligthart, Lannie Loukola, Anu Maher, Brion S. Mbarek, Hamdi McIntosh, Andrew M. McQueen, Matthew B. Meyers, Jacquelyn L. Milaneschi, Yuri Palviainen, Teemu Pearson, John F. Peterson, Roseann E. Ripatti, Samuli Ryu, Euijung Saccone, Nancy L. Salvatore, Jessica E. Sanchez-Roige, Sandra Schwandt, Melanie Sherva, Richard Streit, Fabian Strohmaier, Jana Thomas, Nathaniel Wang, Jen-Chyong Webb, Bradley T. Wedow, Robbee Wetherill, Leah Wills, Amanda G. Boardman, Jason D. Chen, Danfeng Choi, Doo-Sup Copeland, William E. Culverhouse, Robert C. Dahmen, Norbert Degenhardt, Louisa Domingue, Benjamin W. Elson, Sarah L. Frye, Mark A. Gäbel, Wolfgang Hayward, Caroline Ising, Marcus Keyes, Margaret Kiefer, Falk Kramer, John Kuperman, Samuel Lucae, Susanne Lynskey, Michael T. Maier, Wolfgang Mann, Karl Männistö, Satu Müller-Myhsok, Bertram Murray, Alison D. Nurnberger, John I. Palotie, Aarno Preuss, Ulrich Räikkönen, Katri Reynolds, Maureen D. Ridinger, Monika Scherbaum, Norbert Schuckit, Marc A. Soyka, Michael Treutlein, Jens Witt, Stephanie Wodarz, Norbert Zill, Peter Adkins, Daniel E. Boden, Joseph M. Boomsma, Dorret I. Bierut, Laura J. Brown, Sandra A. Bucholz, Kathleen K. Cichon, Sven Costello, E. Jane de Wit, Harriet Diazgranados, Nancy Dick, Danielle M. Eriksson, Johan G. Farrer, Lindsay A. Foroud, Tatiana M. Gillespie, Nathan A. Goate, Alison M. Goldman, David Grucza, Richard A. Hancock, Dana B. Harris, Kathleen Mullan Heath, Andrew C. Hesselbrock, Victor Hewitt, John K. Hopfer, Christian J. Horwood, John Iacono, William Johnson, Eric O. Kaprio, Jaakko A. Karpyak, Victor M. Kendler, Kenneth S. Kranzler, Henry R. Krauter, Kenneth Lichtenstein, Paul Lind, Penelope A. McGue, Matt MacKillop, James Madden, Pamela A. F. Maes, Hermine H. Magnusson, Patrik Martin, Nicholas G. Medland, Sarah E. Montgomery, Grant W. Nelson, Elliot C. Nöthen, Markus M. Palmer, Abraham A. Pedersen, Nancy L. Penninx, Brenda W.J.H. Porjesz, Bernice Rice, John P. Rietschel, Marcella Riley, Brien P. Rose, Richard Rujescu, Dan Shen, Pei-Hong Silberg, Judy Stallings, Michael C. Tarter, Ralph E. Vanyukov, Michael M. Vrieze, Scott Wall, Tamara L. Whitfield, John B. Zhao, Hongyu Neale, Benjamin M. Gelernter, Joel Edenberg, Howard J. Agrawal, Arpana |
| author_facet | Walters, Raymond K. Polimanti, Renato Johnson, Emma C. McClintick, Jeanette N. Adams, Mark J. Adkins, Amy E. Aliev, Fazil Bacanu, Silviu-Alin Batzler, Anthony Bertelsen, Sarah Biernacka, Joanna M. Bigdeli, Tim B. Chen, Li-Shiun Clarke, Toni-Kim Chou, Yi-Ling Degenhardt, Franziska Docherty, Anna R. Edwards, Alexis C. Fontanillas, Pierre Foo, Jerome C. Fox, Louis Frank, Josef Giegling, Ina Gordon, Scott Hack, Laura M. Hartmann, Annette M. Hartz, Sarah M. Heilmann-Heimbach, Stefanie Herms, Stefan Hodgkinson, Colin Hoffmann, Per Hottenga, Jouke Jan Kennedy, Martin A. Alanne-Kinnunen, Mervi Konte, Bettina Lahti, Jari Lahti-Pulkkinen, Marius Lai, Dongbing Ligthart, Lannie Loukola, Anu Maher, Brion S. Mbarek, Hamdi McIntosh, Andrew M. McQueen, Matthew B. Meyers, Jacquelyn L. Milaneschi, Yuri Palviainen, Teemu Pearson, John F. Peterson, Roseann E. Ripatti, Samuli Ryu, Euijung Saccone, Nancy L. Salvatore, Jessica E. Sanchez-Roige, Sandra Schwandt, Melanie Sherva, Richard Streit, Fabian Strohmaier, Jana Thomas, Nathaniel Wang, Jen-Chyong Webb, Bradley T. Wedow, Robbee Wetherill, Leah Wills, Amanda G. Boardman, Jason D. Chen, Danfeng Choi, Doo-Sup Copeland, William E. Culverhouse, Robert C. Dahmen, Norbert Degenhardt, Louisa Domingue, Benjamin W. Elson, Sarah L. Frye, Mark A. Gäbel, Wolfgang Hayward, Caroline Ising, Marcus Keyes, Margaret Kiefer, Falk Kramer, John Kuperman, Samuel Lucae, Susanne Lynskey, Michael T. Maier, Wolfgang Mann, Karl Männistö, Satu Müller-Myhsok, Bertram Murray, Alison D. Nurnberger, John I. Palotie, Aarno Preuss, Ulrich Räikkönen, Katri Reynolds, Maureen D. Ridinger, Monika Scherbaum, Norbert Schuckit, Marc A. Soyka, Michael Treutlein, Jens Witt, Stephanie Wodarz, Norbert Zill, Peter Adkins, Daniel E. Boden, Joseph M. Boomsma, Dorret I. Bierut, Laura J. Brown, Sandra A. Bucholz, Kathleen K. Cichon, Sven Costello, E. Jane de Wit, Harriet Diazgranados, Nancy Dick, Danielle M. Eriksson, Johan G. Farrer, Lindsay A. Foroud, Tatiana M. Gillespie, Nathan A. Goate, Alison M. Goldman, David Grucza, Richard A. Hancock, Dana B. Harris, Kathleen Mullan Heath, Andrew C. Hesselbrock, Victor Hewitt, John K. Hopfer, Christian J. Horwood, John Iacono, William Johnson, Eric O. Kaprio, Jaakko A. Karpyak, Victor M. Kendler, Kenneth S. Kranzler, Henry R. Krauter, Kenneth Lichtenstein, Paul Lind, Penelope A. McGue, Matt MacKillop, James Madden, Pamela A. F. Maes, Hermine H. Magnusson, Patrik Martin, Nicholas G. Medland, Sarah E. Montgomery, Grant W. Nelson, Elliot C. Nöthen, Markus M. Palmer, Abraham A. Pedersen, Nancy L. Penninx, Brenda W.J.H. Porjesz, Bernice Rice, John P. Rietschel, Marcella Riley, Brien P. Rose, Richard Rujescu, Dan Shen, Pei-Hong Silberg, Judy Stallings, Michael C. Tarter, Ralph E. Vanyukov, Michael M. Vrieze, Scott Wall, Tamara L. Whitfield, John B. Zhao, Hongyu Neale, Benjamin M. Gelernter, Joel Edenberg, Howard J. Agrawal, Arpana |
| author_sort | Walters, Raymond K. |
| collection | PubMed |
| description | Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest GWAS to date of DSM-IV diagnosed AD. Genome-wide data on 14,904 individuals with AD and 37,944 controls from 28 case/control and family-based studies were meta-analyzed, stratified by genetic ancestry (European, N = 46,568; African; N = 6,280). Independent, genome-wide significant effects of different ADH1B variants were identified in European (rs1229984; p = 9.8E-13) and African ancestries (rs2066702; p = 2.2E-9). Significant genetic correlations were observed with 17 phenotypes, including schizophrenia, ADHD, depression, and use of cigarettes and cannabis. The genetic underpinnings of AD only partially overlap with those for alcohol consumption, underscoring the genetic distinction between pathological and non-pathological drinking behaviors. |
| format | Online Article Text |
| id | pubmed-6430207 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-64302072019-05-26 Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders Walters, Raymond K. Polimanti, Renato Johnson, Emma C. McClintick, Jeanette N. Adams, Mark J. Adkins, Amy E. Aliev, Fazil Bacanu, Silviu-Alin Batzler, Anthony Bertelsen, Sarah Biernacka, Joanna M. Bigdeli, Tim B. Chen, Li-Shiun Clarke, Toni-Kim Chou, Yi-Ling Degenhardt, Franziska Docherty, Anna R. Edwards, Alexis C. Fontanillas, Pierre Foo, Jerome C. Fox, Louis Frank, Josef Giegling, Ina Gordon, Scott Hack, Laura M. Hartmann, Annette M. Hartz, Sarah M. Heilmann-Heimbach, Stefanie Herms, Stefan Hodgkinson, Colin Hoffmann, Per Hottenga, Jouke Jan Kennedy, Martin A. Alanne-Kinnunen, Mervi Konte, Bettina Lahti, Jari Lahti-Pulkkinen, Marius Lai, Dongbing Ligthart, Lannie Loukola, Anu Maher, Brion S. Mbarek, Hamdi McIntosh, Andrew M. McQueen, Matthew B. Meyers, Jacquelyn L. Milaneschi, Yuri Palviainen, Teemu Pearson, John F. Peterson, Roseann E. Ripatti, Samuli Ryu, Euijung Saccone, Nancy L. Salvatore, Jessica E. Sanchez-Roige, Sandra Schwandt, Melanie Sherva, Richard Streit, Fabian Strohmaier, Jana Thomas, Nathaniel Wang, Jen-Chyong Webb, Bradley T. Wedow, Robbee Wetherill, Leah Wills, Amanda G. Boardman, Jason D. Chen, Danfeng Choi, Doo-Sup Copeland, William E. Culverhouse, Robert C. Dahmen, Norbert Degenhardt, Louisa Domingue, Benjamin W. Elson, Sarah L. Frye, Mark A. Gäbel, Wolfgang Hayward, Caroline Ising, Marcus Keyes, Margaret Kiefer, Falk Kramer, John Kuperman, Samuel Lucae, Susanne Lynskey, Michael T. Maier, Wolfgang Mann, Karl Männistö, Satu Müller-Myhsok, Bertram Murray, Alison D. Nurnberger, John I. Palotie, Aarno Preuss, Ulrich Räikkönen, Katri Reynolds, Maureen D. Ridinger, Monika Scherbaum, Norbert Schuckit, Marc A. Soyka, Michael Treutlein, Jens Witt, Stephanie Wodarz, Norbert Zill, Peter Adkins, Daniel E. Boden, Joseph M. Boomsma, Dorret I. Bierut, Laura J. Brown, Sandra A. Bucholz, Kathleen K. Cichon, Sven Costello, E. Jane de Wit, Harriet Diazgranados, Nancy Dick, Danielle M. Eriksson, Johan G. Farrer, Lindsay A. Foroud, Tatiana M. Gillespie, Nathan A. Goate, Alison M. Goldman, David Grucza, Richard A. Hancock, Dana B. Harris, Kathleen Mullan Heath, Andrew C. Hesselbrock, Victor Hewitt, John K. Hopfer, Christian J. Horwood, John Iacono, William Johnson, Eric O. Kaprio, Jaakko A. Karpyak, Victor M. Kendler, Kenneth S. Kranzler, Henry R. Krauter, Kenneth Lichtenstein, Paul Lind, Penelope A. McGue, Matt MacKillop, James Madden, Pamela A. F. Maes, Hermine H. Magnusson, Patrik Martin, Nicholas G. Medland, Sarah E. Montgomery, Grant W. Nelson, Elliot C. Nöthen, Markus M. Palmer, Abraham A. Pedersen, Nancy L. Penninx, Brenda W.J.H. Porjesz, Bernice Rice, John P. Rietschel, Marcella Riley, Brien P. Rose, Richard Rujescu, Dan Shen, Pei-Hong Silberg, Judy Stallings, Michael C. Tarter, Ralph E. Vanyukov, Michael M. Vrieze, Scott Wall, Tamara L. Whitfield, John B. Zhao, Hongyu Neale, Benjamin M. Gelernter, Joel Edenberg, Howard J. Agrawal, Arpana Nat Neurosci Article Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest GWAS to date of DSM-IV diagnosed AD. Genome-wide data on 14,904 individuals with AD and 37,944 controls from 28 case/control and family-based studies were meta-analyzed, stratified by genetic ancestry (European, N = 46,568; African; N = 6,280). Independent, genome-wide significant effects of different ADH1B variants were identified in European (rs1229984; p = 9.8E-13) and African ancestries (rs2066702; p = 2.2E-9). Significant genetic correlations were observed with 17 phenotypes, including schizophrenia, ADHD, depression, and use of cigarettes and cannabis. The genetic underpinnings of AD only partially overlap with those for alcohol consumption, underscoring the genetic distinction between pathological and non-pathological drinking behaviors. 2018-11-26 2018-12 /pmc/articles/PMC6430207/ /pubmed/30482948 http://dx.doi.org/10.1038/s41593-018-0275-1 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Walters, Raymond K. Polimanti, Renato Johnson, Emma C. McClintick, Jeanette N. Adams, Mark J. Adkins, Amy E. Aliev, Fazil Bacanu, Silviu-Alin Batzler, Anthony Bertelsen, Sarah Biernacka, Joanna M. Bigdeli, Tim B. Chen, Li-Shiun Clarke, Toni-Kim Chou, Yi-Ling Degenhardt, Franziska Docherty, Anna R. Edwards, Alexis C. Fontanillas, Pierre Foo, Jerome C. Fox, Louis Frank, Josef Giegling, Ina Gordon, Scott Hack, Laura M. Hartmann, Annette M. Hartz, Sarah M. Heilmann-Heimbach, Stefanie Herms, Stefan Hodgkinson, Colin Hoffmann, Per Hottenga, Jouke Jan Kennedy, Martin A. Alanne-Kinnunen, Mervi Konte, Bettina Lahti, Jari Lahti-Pulkkinen, Marius Lai, Dongbing Ligthart, Lannie Loukola, Anu Maher, Brion S. Mbarek, Hamdi McIntosh, Andrew M. McQueen, Matthew B. Meyers, Jacquelyn L. Milaneschi, Yuri Palviainen, Teemu Pearson, John F. Peterson, Roseann E. Ripatti, Samuli Ryu, Euijung Saccone, Nancy L. Salvatore, Jessica E. Sanchez-Roige, Sandra Schwandt, Melanie Sherva, Richard Streit, Fabian Strohmaier, Jana Thomas, Nathaniel Wang, Jen-Chyong Webb, Bradley T. Wedow, Robbee Wetherill, Leah Wills, Amanda G. Boardman, Jason D. Chen, Danfeng Choi, Doo-Sup Copeland, William E. Culverhouse, Robert C. Dahmen, Norbert Degenhardt, Louisa Domingue, Benjamin W. Elson, Sarah L. Frye, Mark A. Gäbel, Wolfgang Hayward, Caroline Ising, Marcus Keyes, Margaret Kiefer, Falk Kramer, John Kuperman, Samuel Lucae, Susanne Lynskey, Michael T. Maier, Wolfgang Mann, Karl Männistö, Satu Müller-Myhsok, Bertram Murray, Alison D. Nurnberger, John I. Palotie, Aarno Preuss, Ulrich Räikkönen, Katri Reynolds, Maureen D. Ridinger, Monika Scherbaum, Norbert Schuckit, Marc A. Soyka, Michael Treutlein, Jens Witt, Stephanie Wodarz, Norbert Zill, Peter Adkins, Daniel E. Boden, Joseph M. Boomsma, Dorret I. Bierut, Laura J. Brown, Sandra A. Bucholz, Kathleen K. Cichon, Sven Costello, E. Jane de Wit, Harriet Diazgranados, Nancy Dick, Danielle M. Eriksson, Johan G. Farrer, Lindsay A. Foroud, Tatiana M. Gillespie, Nathan A. Goate, Alison M. Goldman, David Grucza, Richard A. Hancock, Dana B. Harris, Kathleen Mullan Heath, Andrew C. Hesselbrock, Victor Hewitt, John K. Hopfer, Christian J. Horwood, John Iacono, William Johnson, Eric O. Kaprio, Jaakko A. Karpyak, Victor M. Kendler, Kenneth S. Kranzler, Henry R. Krauter, Kenneth Lichtenstein, Paul Lind, Penelope A. McGue, Matt MacKillop, James Madden, Pamela A. F. Maes, Hermine H. Magnusson, Patrik Martin, Nicholas G. Medland, Sarah E. Montgomery, Grant W. Nelson, Elliot C. Nöthen, Markus M. Palmer, Abraham A. Pedersen, Nancy L. Penninx, Brenda W.J.H. Porjesz, Bernice Rice, John P. Rietschel, Marcella Riley, Brien P. Rose, Richard Rujescu, Dan Shen, Pei-Hong Silberg, Judy Stallings, Michael C. Tarter, Ralph E. Vanyukov, Michael M. Vrieze, Scott Wall, Tamara L. Whitfield, John B. Zhao, Hongyu Neale, Benjamin M. Gelernter, Joel Edenberg, Howard J. Agrawal, Arpana Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders |
| title | Trans-ancestral GWAS of alcohol dependence reveals common genetic
underpinnings with psychiatric disorders |
| title_full | Trans-ancestral GWAS of alcohol dependence reveals common genetic
underpinnings with psychiatric disorders |
| title_fullStr | Trans-ancestral GWAS of alcohol dependence reveals common genetic
underpinnings with psychiatric disorders |
| title_full_unstemmed | Trans-ancestral GWAS of alcohol dependence reveals common genetic
underpinnings with psychiatric disorders |
| title_short | Trans-ancestral GWAS of alcohol dependence reveals common genetic
underpinnings with psychiatric disorders |
| title_sort | trans-ancestral gwas of alcohol dependence reveals common genetic
underpinnings with psychiatric disorders |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430207/ https://www.ncbi.nlm.nih.gov/pubmed/30482948 http://dx.doi.org/10.1038/s41593-018-0275-1 |
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