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Development of a Label-Free LC-MS/MS-Based Glucosylceramide Synthase Assay and Its Application to Inhibitors Screening for Ceramide-Related Diseases

Ceramide metabolism is known to be an essential etiology for various diseases, such as atopic dermatitis and Gaucher disease. Glucosylceramide synthase (GCS) is a key enzyme for the synthesis of glucosylceramide (GlcCer), which is a main ceramide metabolism pathway in mammalian cells. In this articl...

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Detalles Bibliográficos
Autores principales:	Fu, Zhicheng, Yun, So Yoon, Won, Jong Hoon, Back, Moon Jung, Jang, Ji Min, Ha, Hae Chan, Lee, Hae Kyung, Shin, In Chul, Kim, Ju Yeun, Kim, Hee Soo, Kim, Dae Kyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society of Applied Pharmacology 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430231/ https://www.ncbi.nlm.nih.gov/pubmed/30231605 http://dx.doi.org/10.4062/biomolther.2018.122

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