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Stress matters: Randomized controlled trial on the effect of probiotics on neurocognition

Probiotics are microorganisms that provide health benefits when consumed. In animals, probiotics reverse gut microbiome-related alterations in depression-like symptoms, in cognition, and in hormonal stress response. However, in humans, a causal understanding of the gut-brain link in emotion and cogn...

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Autores principales: Papalini, S., Michels, F., Kohn, N., Wegman, J., van Hemert, S., Roelofs, K., Arias-Vasquez, A., Aarts, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430409/
https://www.ncbi.nlm.nih.gov/pubmed/30937347
http://dx.doi.org/10.1016/j.ynstr.2018.100141
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author Papalini, S.
Michels, F.
Kohn, N.
Wegman, J.
van Hemert, S.
Roelofs, K.
Arias-Vasquez, A.
Aarts, E.
author_facet Papalini, S.
Michels, F.
Kohn, N.
Wegman, J.
van Hemert, S.
Roelofs, K.
Arias-Vasquez, A.
Aarts, E.
author_sort Papalini, S.
collection PubMed
description Probiotics are microorganisms that provide health benefits when consumed. In animals, probiotics reverse gut microbiome-related alterations in depression-like symptoms, in cognition, and in hormonal stress response. However, in humans, a causal understanding of the gut-brain link in emotion and cognition is lacking. Additionally, whether the effects of probiotics on neurocognition are visible only in presence of stress, remains unclear. We investigated the effects of a multispecies probiotic (Ecologic(®)Barrier) on specific neurocognitive measures of emotion reactivity, emotion regulation, and cognitive control using fMRI. Critically, we also tested whether probiotics can buffer against the detrimental effects of acute stress on working memory. In a double blind, randomized, placebo-controlled, between-subjects intervention study, 58 healthy participants were tested once before and once after a 28-day intervention. Without stress induction, probiotics did not affect brain, behavioral, or related self-report measures. However, relative to placebo, the probiotics group did show a significant stress-related increase in working memory performance after supplementation. This change was associated with intervention-related neural changes in frontal cortex during cognitive control exclusively in the probiotics group. Overall, our results show neurocognitive effects of a multispecies probiotic in healthy women only under challenging situations, buffering against the detrimental effects of stress on cognition.
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spelling pubmed-64304092019-04-01 Stress matters: Randomized controlled trial on the effect of probiotics on neurocognition Papalini, S. Michels, F. Kohn, N. Wegman, J. van Hemert, S. Roelofs, K. Arias-Vasquez, A. Aarts, E. Neurobiol Stress Original Research Article Probiotics are microorganisms that provide health benefits when consumed. In animals, probiotics reverse gut microbiome-related alterations in depression-like symptoms, in cognition, and in hormonal stress response. However, in humans, a causal understanding of the gut-brain link in emotion and cognition is lacking. Additionally, whether the effects of probiotics on neurocognition are visible only in presence of stress, remains unclear. We investigated the effects of a multispecies probiotic (Ecologic(®)Barrier) on specific neurocognitive measures of emotion reactivity, emotion regulation, and cognitive control using fMRI. Critically, we also tested whether probiotics can buffer against the detrimental effects of acute stress on working memory. In a double blind, randomized, placebo-controlled, between-subjects intervention study, 58 healthy participants were tested once before and once after a 28-day intervention. Without stress induction, probiotics did not affect brain, behavioral, or related self-report measures. However, relative to placebo, the probiotics group did show a significant stress-related increase in working memory performance after supplementation. This change was associated with intervention-related neural changes in frontal cortex during cognitive control exclusively in the probiotics group. Overall, our results show neurocognitive effects of a multispecies probiotic in healthy women only under challenging situations, buffering against the detrimental effects of stress on cognition. Elsevier 2018-12-10 /pmc/articles/PMC6430409/ /pubmed/30937347 http://dx.doi.org/10.1016/j.ynstr.2018.100141 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Article
Papalini, S.
Michels, F.
Kohn, N.
Wegman, J.
van Hemert, S.
Roelofs, K.
Arias-Vasquez, A.
Aarts, E.
Stress matters: Randomized controlled trial on the effect of probiotics on neurocognition
title Stress matters: Randomized controlled trial on the effect of probiotics on neurocognition
title_full Stress matters: Randomized controlled trial on the effect of probiotics on neurocognition
title_fullStr Stress matters: Randomized controlled trial on the effect of probiotics on neurocognition
title_full_unstemmed Stress matters: Randomized controlled trial on the effect of probiotics on neurocognition
title_short Stress matters: Randomized controlled trial on the effect of probiotics on neurocognition
title_sort stress matters: randomized controlled trial on the effect of probiotics on neurocognition
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430409/
https://www.ncbi.nlm.nih.gov/pubmed/30937347
http://dx.doi.org/10.1016/j.ynstr.2018.100141
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