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Efficacy of vitamin D supplementation in gestational diabetes mellitus: Systematic review and meta-analysis of randomized trials

BACKGROUND: Trials have examined on the benefits of vitamin D supplementation in pregnant women. OBJECTIVE: This review aimed to evaluate whether oral vitamin D supplements, when given to pregnant women with gestational diabetes mellitus (GDM), would improve maternal and neonatal outcomes, compared...

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Autores principales: Rodrigues, Meline Rossetto Kron, Lima, Silvana Andréa Molina, Mazeto, Glaucia Maria Ferreira da Silvia, Calderon, Iracema Mattos Paranhos, Magalhães, Claudia Garcia, Ferraz, Guilherme Augusto Rago, Molina, Ana Claúdia, Costa, Roberto Antônio de Araújo, Nogueira, Vania dos Santos Nunes, Rudge, Marilza Vieira Cunha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430411/
https://www.ncbi.nlm.nih.gov/pubmed/30901325
http://dx.doi.org/10.1371/journal.pone.0213006
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author Rodrigues, Meline Rossetto Kron
Lima, Silvana Andréa Molina
Mazeto, Glaucia Maria Ferreira da Silvia
Calderon, Iracema Mattos Paranhos
Magalhães, Claudia Garcia
Ferraz, Guilherme Augusto Rago
Molina, Ana Claúdia
Costa, Roberto Antônio de Araújo
Nogueira, Vania dos Santos Nunes
Rudge, Marilza Vieira Cunha
author_facet Rodrigues, Meline Rossetto Kron
Lima, Silvana Andréa Molina
Mazeto, Glaucia Maria Ferreira da Silvia
Calderon, Iracema Mattos Paranhos
Magalhães, Claudia Garcia
Ferraz, Guilherme Augusto Rago
Molina, Ana Claúdia
Costa, Roberto Antônio de Araújo
Nogueira, Vania dos Santos Nunes
Rudge, Marilza Vieira Cunha
author_sort Rodrigues, Meline Rossetto Kron
collection PubMed
description BACKGROUND: Trials have examined on the benefits of vitamin D supplementation in pregnant women. OBJECTIVE: This review aimed to evaluate whether oral vitamin D supplements, when given to pregnant women with gestational diabetes mellitus (GDM), would improve maternal and neonatal outcomes, compared with no treatment or placebo. METHOD: We performed a systematic review following Cochrane methodology, and randomized trials were included where pregnant women with GDM received vitamin D supplementation versus placebo/no treatment or vitamin D and calcium versus placebo/no treatment. Primary outcomes were preeclampsia, preterm birth, cesarean delivery, gestational hypertension, and adverse events related to vitamin D supplementation. The search strategies were applied to the following databases: MEDLINE, Embase, LILACS, and CENTRAL. Similar outcomes in at least two trials were plotted using Review Manager 5.3 software. The quality of evidence was generated according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). RESULTS: The total of 1224 references were identified, eleven trials were potentially eligible, and six were included in this review (totaling 456 women). The meta-analysis of frequency of cesarean deliveries did not show significant differences between groups, none of the trials evaluated the remaining primary outcomes. For secondary outcomes, our results suggest that vitamin D supplementation in pregnant women with GDM may reduce newborn complications such as hyperbilirubinemia, polyhydramnios (RR: 0.40, 95% CI: 0.23 to 0.68; RR: 0.17, 95% CI: 0.03 to 0.89; respectively), and the need for maternal or infant hospitalization (RR: 0.13; 95% CI: 0.02 to 0.98; RR: 0.40, 95% CI: 0.23 to 0.69). However, the evidence was of low or very low quality. CONCLUSION: We did not find moderate or high quality evidence indicating that vitamin D supplementation, when compared with placebo, improves glucose metabolism, adverse maternal and neonatal outcomes related to GDM in pregnant women.
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spelling pubmed-64304112019-04-01 Efficacy of vitamin D supplementation in gestational diabetes mellitus: Systematic review and meta-analysis of randomized trials Rodrigues, Meline Rossetto Kron Lima, Silvana Andréa Molina Mazeto, Glaucia Maria Ferreira da Silvia Calderon, Iracema Mattos Paranhos Magalhães, Claudia Garcia Ferraz, Guilherme Augusto Rago Molina, Ana Claúdia Costa, Roberto Antônio de Araújo Nogueira, Vania dos Santos Nunes Rudge, Marilza Vieira Cunha PLoS One Research Article BACKGROUND: Trials have examined on the benefits of vitamin D supplementation in pregnant women. OBJECTIVE: This review aimed to evaluate whether oral vitamin D supplements, when given to pregnant women with gestational diabetes mellitus (GDM), would improve maternal and neonatal outcomes, compared with no treatment or placebo. METHOD: We performed a systematic review following Cochrane methodology, and randomized trials were included where pregnant women with GDM received vitamin D supplementation versus placebo/no treatment or vitamin D and calcium versus placebo/no treatment. Primary outcomes were preeclampsia, preterm birth, cesarean delivery, gestational hypertension, and adverse events related to vitamin D supplementation. The search strategies were applied to the following databases: MEDLINE, Embase, LILACS, and CENTRAL. Similar outcomes in at least two trials were plotted using Review Manager 5.3 software. The quality of evidence was generated according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). RESULTS: The total of 1224 references were identified, eleven trials were potentially eligible, and six were included in this review (totaling 456 women). The meta-analysis of frequency of cesarean deliveries did not show significant differences between groups, none of the trials evaluated the remaining primary outcomes. For secondary outcomes, our results suggest that vitamin D supplementation in pregnant women with GDM may reduce newborn complications such as hyperbilirubinemia, polyhydramnios (RR: 0.40, 95% CI: 0.23 to 0.68; RR: 0.17, 95% CI: 0.03 to 0.89; respectively), and the need for maternal or infant hospitalization (RR: 0.13; 95% CI: 0.02 to 0.98; RR: 0.40, 95% CI: 0.23 to 0.69). However, the evidence was of low or very low quality. CONCLUSION: We did not find moderate or high quality evidence indicating that vitamin D supplementation, when compared with placebo, improves glucose metabolism, adverse maternal and neonatal outcomes related to GDM in pregnant women. Public Library of Science 2019-03-22 /pmc/articles/PMC6430411/ /pubmed/30901325 http://dx.doi.org/10.1371/journal.pone.0213006 Text en © 2019 Rodrigues et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Rodrigues, Meline Rossetto Kron
Lima, Silvana Andréa Molina
Mazeto, Glaucia Maria Ferreira da Silvia
Calderon, Iracema Mattos Paranhos
Magalhães, Claudia Garcia
Ferraz, Guilherme Augusto Rago
Molina, Ana Claúdia
Costa, Roberto Antônio de Araújo
Nogueira, Vania dos Santos Nunes
Rudge, Marilza Vieira Cunha
Efficacy of vitamin D supplementation in gestational diabetes mellitus: Systematic review and meta-analysis of randomized trials
title Efficacy of vitamin D supplementation in gestational diabetes mellitus: Systematic review and meta-analysis of randomized trials
title_full Efficacy of vitamin D supplementation in gestational diabetes mellitus: Systematic review and meta-analysis of randomized trials
title_fullStr Efficacy of vitamin D supplementation in gestational diabetes mellitus: Systematic review and meta-analysis of randomized trials
title_full_unstemmed Efficacy of vitamin D supplementation in gestational diabetes mellitus: Systematic review and meta-analysis of randomized trials
title_short Efficacy of vitamin D supplementation in gestational diabetes mellitus: Systematic review and meta-analysis of randomized trials
title_sort efficacy of vitamin d supplementation in gestational diabetes mellitus: systematic review and meta-analysis of randomized trials
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430411/
https://www.ncbi.nlm.nih.gov/pubmed/30901325
http://dx.doi.org/10.1371/journal.pone.0213006
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