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Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer

[Image: see text] Besides size and polymorphic form, crystal shape takes a central role in engineering advanced solid materials for the pharmaceutical and chemical industries. This work demonstrates how multiple cycles of growth and dissolution can manipulate the habit of an acetylsalicylic acid cry...

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Autores principales: Neugebauer, Peter, Cardona, Javier, Besenhard, Maximilian O., Peter, Anna, Gruber-Woelfler, Heidrun, Tachtatzis, Christos, Cleary, Alison, Andonovic, Ivan, Sefcik, Jan, Khinast, Johannes G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430499/
https://www.ncbi.nlm.nih.gov/pubmed/30918477
http://dx.doi.org/10.1021/acs.cgd.8b00371
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author Neugebauer, Peter
Cardona, Javier
Besenhard, Maximilian O.
Peter, Anna
Gruber-Woelfler, Heidrun
Tachtatzis, Christos
Cleary, Alison
Andonovic, Ivan
Sefcik, Jan
Khinast, Johannes G.
author_facet Neugebauer, Peter
Cardona, Javier
Besenhard, Maximilian O.
Peter, Anna
Gruber-Woelfler, Heidrun
Tachtatzis, Christos
Cleary, Alison
Andonovic, Ivan
Sefcik, Jan
Khinast, Johannes G.
author_sort Neugebauer, Peter
collection PubMed
description [Image: see text] Besides size and polymorphic form, crystal shape takes a central role in engineering advanced solid materials for the pharmaceutical and chemical industries. This work demonstrates how multiple cycles of growth and dissolution can manipulate the habit of an acetylsalicylic acid crystal population. Considerable changes of the crystal habit could be achieved within minutes due to rapid cycling, i.e., up to 25 cycles within <10 min. The required fast heating and cooling rates were facilitated using a tubular reactor design allowing for superior temperature control. The face-specific interactions between solvent and the crystals’ surface result in face-specific growth and dissolution rates and hence alterations of the final shape of the crystals in solution. Accurate quantification of the crystal shapes was essential for this work, but is everything except simple. A commercial size and shape analyzer had to be adapted to achieve the required accuracy. Online size, and most important shape, analysis was achieved using an automated microscope equipped with a flow-through cell, in combination with a dedicated image analysis routine for particle tracking and shape analysis. Due to the implementation of this analyzer, capable of obtaining statistics on the crystals’ shape while still in solution (no sampling and manipulation required), the dynamic behavior of the size shape distribution could be studied. This enabled a detailed analysis of the solvent’s effect on the change in crystal habit.
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spelling pubmed-64304992019-03-25 Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer Neugebauer, Peter Cardona, Javier Besenhard, Maximilian O. Peter, Anna Gruber-Woelfler, Heidrun Tachtatzis, Christos Cleary, Alison Andonovic, Ivan Sefcik, Jan Khinast, Johannes G. Cryst Growth Des [Image: see text] Besides size and polymorphic form, crystal shape takes a central role in engineering advanced solid materials for the pharmaceutical and chemical industries. This work demonstrates how multiple cycles of growth and dissolution can manipulate the habit of an acetylsalicylic acid crystal population. Considerable changes of the crystal habit could be achieved within minutes due to rapid cycling, i.e., up to 25 cycles within <10 min. The required fast heating and cooling rates were facilitated using a tubular reactor design allowing for superior temperature control. The face-specific interactions between solvent and the crystals’ surface result in face-specific growth and dissolution rates and hence alterations of the final shape of the crystals in solution. Accurate quantification of the crystal shapes was essential for this work, but is everything except simple. A commercial size and shape analyzer had to be adapted to achieve the required accuracy. Online size, and most important shape, analysis was achieved using an automated microscope equipped with a flow-through cell, in combination with a dedicated image analysis routine for particle tracking and shape analysis. Due to the implementation of this analyzer, capable of obtaining statistics on the crystals’ shape while still in solution (no sampling and manipulation required), the dynamic behavior of the size shape distribution could be studied. This enabled a detailed analysis of the solvent’s effect on the change in crystal habit. American Chemical Society 2018-06-15 2018-08-01 /pmc/articles/PMC6430499/ /pubmed/30918477 http://dx.doi.org/10.1021/acs.cgd.8b00371 Text en Copyright © 2018 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Neugebauer, Peter
Cardona, Javier
Besenhard, Maximilian O.
Peter, Anna
Gruber-Woelfler, Heidrun
Tachtatzis, Christos
Cleary, Alison
Andonovic, Ivan
Sefcik, Jan
Khinast, Johannes G.
Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer
title Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer
title_full Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer
title_fullStr Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer
title_full_unstemmed Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer
title_short Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer
title_sort crystal shape modification via cycles of growth and dissolution in a tubular crystallizer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430499/
https://www.ncbi.nlm.nih.gov/pubmed/30918477
http://dx.doi.org/10.1021/acs.cgd.8b00371
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