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3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation

[Image: see text] Hydroxylation and fluorination of proline alters the pyrrolidine ring pucker and the trans:cis amide bond ratio in a stereochemistry-dependent fashion, affecting molecular recognition of proline-containing molecules by biological systems. While hydroxyprolines and fluoroprolines ar...

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Detalles Bibliográficos
Autores principales:	Testa, Andrea, Lucas, Xavier, Castro, Guilherme V., Chan, Kwok-Ho, Wright, Jane E., Runcie, Andrew C., Gadd, Morgan S., Harrison, William T. A., Ko, Eun-Jung, Fletcher, Daniel, Ciulli, Alessio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430500/ https://www.ncbi.nlm.nih.gov/pubmed/29949369 http://dx.doi.org/10.1021/jacs.8b05807

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