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Myc-driven chromatin accessibility regulates Cdc45 assembly into CMG helicases

Myc-driven tumorigenesis involves a non-transcriptional role for Myc in over-activating replication origins. We show here that the mechanism underlying this process involves a direct role for Myc in activation of Cdc45-MCM-GINS (CMG) helicases at Myc-targeted sites. Myc induces decondensation of hig...

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Detalles Bibliográficos
Autores principales:	Nepon-Sixt, Brook S., Bryant, Victoria L., Alexandrow, Mark G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430796/ https://www.ncbi.nlm.nih.gov/pubmed/30911685 http://dx.doi.org/10.1038/s42003-019-0353-2

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