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Development and validation of a novel clinical scoring system for short‐term prediction of death in dogs with acute pancreatitis

BACKGROUND: Acute pancreatitis (AP) is associated with a high death rate in dogs, but accurate predictors of early death are still lacking. OBJECTIVES: To develop a scoring system for prediction of short‐term case fatality in dogs with AP. ANIMALS: One hundred sixty‐nine dogs with AP including 138 d...

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Autores principales: Fabrès, Virginie, Dossin, Olivier, Reif, Clémence, Campos, Miguel, Freiche, Valerie, Maurey, Christelle, Pilot‐Storck, Fanny, Desquilbet, Loïc, Benchekroun, Ghita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430934/
https://www.ncbi.nlm.nih.gov/pubmed/30770578
http://dx.doi.org/10.1111/jvim.15421
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author Fabrès, Virginie
Dossin, Olivier
Reif, Clémence
Campos, Miguel
Freiche, Valerie
Maurey, Christelle
Pilot‐Storck, Fanny
Desquilbet, Loïc
Benchekroun, Ghita
author_facet Fabrès, Virginie
Dossin, Olivier
Reif, Clémence
Campos, Miguel
Freiche, Valerie
Maurey, Christelle
Pilot‐Storck, Fanny
Desquilbet, Loïc
Benchekroun, Ghita
author_sort Fabrès, Virginie
collection PubMed
description BACKGROUND: Acute pancreatitis (AP) is associated with a high death rate in dogs, but accurate predictors of early death are still lacking. OBJECTIVES: To develop a scoring system for prediction of short‐term case fatality in dogs with AP. ANIMALS: One hundred sixty‐nine dogs with AP including 138 dogs in the training cohort and 31 dogs in the validation cohort. METHODS: Multicenter, retrospective cohort study. Survival analysis was used to assess the associations with short‐term death (within 30 days after admission). Independent predictors of death were identified by a stepwise selection method and used for the score calculation. RESULTS: Death rate within 30 days after admission was 33% in the training cohort. Four independent risk factors for short‐term death were identified in the training cohort: presence of systemic inflammatory response syndrome, coagulation disorders, increased creatinine and ionized hypocalcemia. Canine Acute Pancreatitis Severity (CAPS) score was developed to predict short‐term death, integrating these 4 factors in a weighted way. A simplified version of CAPS score (sCAPS) including respiratory rate instead of SIRS was also assessed. The area under the receiver‐operating characteristic curve (AUC) of CAPS and sCAPS scores was 0.92 in the training cohort with an optimal cutoff of 11 (sensitivity, 89%; specificity, 90%) and 6 (sensitivity, 96%; specificity, 77%), respectively. CAPS and sCAPS score were validated in the validation cohort with respective AUC of 0.91 and 0.96. CONCLUSIONS AND CLINICAL IMPORTANCE: We propose 2 scoring systems that allow early and accurate prediction of short‐term death in dogs with AP.
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spelling pubmed-64309342019-04-04 Development and validation of a novel clinical scoring system for short‐term prediction of death in dogs with acute pancreatitis Fabrès, Virginie Dossin, Olivier Reif, Clémence Campos, Miguel Freiche, Valerie Maurey, Christelle Pilot‐Storck, Fanny Desquilbet, Loïc Benchekroun, Ghita J Vet Intern Med SMALL ANIMAL BACKGROUND: Acute pancreatitis (AP) is associated with a high death rate in dogs, but accurate predictors of early death are still lacking. OBJECTIVES: To develop a scoring system for prediction of short‐term case fatality in dogs with AP. ANIMALS: One hundred sixty‐nine dogs with AP including 138 dogs in the training cohort and 31 dogs in the validation cohort. METHODS: Multicenter, retrospective cohort study. Survival analysis was used to assess the associations with short‐term death (within 30 days after admission). Independent predictors of death were identified by a stepwise selection method and used for the score calculation. RESULTS: Death rate within 30 days after admission was 33% in the training cohort. Four independent risk factors for short‐term death were identified in the training cohort: presence of systemic inflammatory response syndrome, coagulation disorders, increased creatinine and ionized hypocalcemia. Canine Acute Pancreatitis Severity (CAPS) score was developed to predict short‐term death, integrating these 4 factors in a weighted way. A simplified version of CAPS score (sCAPS) including respiratory rate instead of SIRS was also assessed. The area under the receiver‐operating characteristic curve (AUC) of CAPS and sCAPS scores was 0.92 in the training cohort with an optimal cutoff of 11 (sensitivity, 89%; specificity, 90%) and 6 (sensitivity, 96%; specificity, 77%), respectively. CAPS and sCAPS score were validated in the validation cohort with respective AUC of 0.91 and 0.96. CONCLUSIONS AND CLINICAL IMPORTANCE: We propose 2 scoring systems that allow early and accurate prediction of short‐term death in dogs with AP. John Wiley & Sons, Inc. 2019-02-15 2019 /pmc/articles/PMC6430934/ /pubmed/30770578 http://dx.doi.org/10.1111/jvim.15421 Text en © 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle SMALL ANIMAL
Fabrès, Virginie
Dossin, Olivier
Reif, Clémence
Campos, Miguel
Freiche, Valerie
Maurey, Christelle
Pilot‐Storck, Fanny
Desquilbet, Loïc
Benchekroun, Ghita
Development and validation of a novel clinical scoring system for short‐term prediction of death in dogs with acute pancreatitis
title Development and validation of a novel clinical scoring system for short‐term prediction of death in dogs with acute pancreatitis
title_full Development and validation of a novel clinical scoring system for short‐term prediction of death in dogs with acute pancreatitis
title_fullStr Development and validation of a novel clinical scoring system for short‐term prediction of death in dogs with acute pancreatitis
title_full_unstemmed Development and validation of a novel clinical scoring system for short‐term prediction of death in dogs with acute pancreatitis
title_short Development and validation of a novel clinical scoring system for short‐term prediction of death in dogs with acute pancreatitis
title_sort development and validation of a novel clinical scoring system for short‐term prediction of death in dogs with acute pancreatitis
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430934/
https://www.ncbi.nlm.nih.gov/pubmed/30770578
http://dx.doi.org/10.1111/jvim.15421
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