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Comparison of cancer detection rates by transrectal prostate biopsy for prostate cancer using two different nomograms based on patient’s age and prostate volume

BACKGROUND: The aim of this study is to evaluate the efficacy of two different Nara Urological Research and Treatment Group (NURTG) nomograms allocating 6–12 biopsy cores based on age and prostate volume. MATERIALS AND METHODS: From April 2006 to July 2014, a total of 1,605 patients who underwent in...

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Autores principales: Hori, Shunta, Tanaka, Nobumichi, Nakai, Yasushi, Morizawa, Yosuke, Tatsumi, Yoshihiro, Miyake, Makito, Anai, Satoshi, Fujii, Tomomi, Konishi, Noboru, Nakagawa, Yoshinori, Hirao, Syuya, Fujimoto, Kiyohide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430996/
https://www.ncbi.nlm.nih.gov/pubmed/30937289
http://dx.doi.org/10.2147/RRU.S193933
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author Hori, Shunta
Tanaka, Nobumichi
Nakai, Yasushi
Morizawa, Yosuke
Tatsumi, Yoshihiro
Miyake, Makito
Anai, Satoshi
Fujii, Tomomi
Konishi, Noboru
Nakagawa, Yoshinori
Hirao, Syuya
Fujimoto, Kiyohide
author_facet Hori, Shunta
Tanaka, Nobumichi
Nakai, Yasushi
Morizawa, Yosuke
Tatsumi, Yoshihiro
Miyake, Makito
Anai, Satoshi
Fujii, Tomomi
Konishi, Noboru
Nakagawa, Yoshinori
Hirao, Syuya
Fujimoto, Kiyohide
author_sort Hori, Shunta
collection PubMed
description BACKGROUND: The aim of this study is to evaluate the efficacy of two different Nara Urological Research and Treatment Group (NURTG) nomograms allocating 6–12 biopsy cores based on age and prostate volume. MATERIALS AND METHODS: From April 2006 to July 2014, a total of 1,605 patients who underwent initial prostate biopsy were enrolled. Based on a nomogram taking the patient’s age and prostate volume into consideration, 6–12 biopsy cores were allocated. Two types of nomogram were used, for the former group (before March 2009) and latter group (March 2009 onward). Cancer detection rates in all patients and those with prostate-specific antigen values in the gray zone (4.0–10 ng/mL) were compared. Predictive parameters for detection of prostate cancer in gray-zone patients were also investigated. RESULTS: The cancer detection rates in all patients and those in the gray zone were 48% and 38% in the former group and 54% and 41% in the latter group, respectively. The cancer detection rate in all patients was significantly higher in the latter group compared with the former group, but detection in gray-zone patients did not show a significant difference between the two groups (P=0.011 and P=0.37, respectively). Multivariate analysis indicated that age, digital rectal examination, prostate volume, transrectal ultrasonography findings, and volume/biopsy ratio were significant predictive parameters in gray-zone patients. The clinically insignificant cancer detection rate was significantly lower in the latter group compared with the former group (P=0.0008). CONCLUSION: The latter nomogram provided more acceptable detection rates of clinically significant and insignificant cancer than the former one, and we consider that an initial maximum 12-core transrectal ultrasound-guided needle biopsy may be sufficient for prostate cancer diagnosis.
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spelling pubmed-64309962019-04-01 Comparison of cancer detection rates by transrectal prostate biopsy for prostate cancer using two different nomograms based on patient’s age and prostate volume Hori, Shunta Tanaka, Nobumichi Nakai, Yasushi Morizawa, Yosuke Tatsumi, Yoshihiro Miyake, Makito Anai, Satoshi Fujii, Tomomi Konishi, Noboru Nakagawa, Yoshinori Hirao, Syuya Fujimoto, Kiyohide Res Rep Urol Original Research BACKGROUND: The aim of this study is to evaluate the efficacy of two different Nara Urological Research and Treatment Group (NURTG) nomograms allocating 6–12 biopsy cores based on age and prostate volume. MATERIALS AND METHODS: From April 2006 to July 2014, a total of 1,605 patients who underwent initial prostate biopsy were enrolled. Based on a nomogram taking the patient’s age and prostate volume into consideration, 6–12 biopsy cores were allocated. Two types of nomogram were used, for the former group (before March 2009) and latter group (March 2009 onward). Cancer detection rates in all patients and those with prostate-specific antigen values in the gray zone (4.0–10 ng/mL) were compared. Predictive parameters for detection of prostate cancer in gray-zone patients were also investigated. RESULTS: The cancer detection rates in all patients and those in the gray zone were 48% and 38% in the former group and 54% and 41% in the latter group, respectively. The cancer detection rate in all patients was significantly higher in the latter group compared with the former group, but detection in gray-zone patients did not show a significant difference between the two groups (P=0.011 and P=0.37, respectively). Multivariate analysis indicated that age, digital rectal examination, prostate volume, transrectal ultrasonography findings, and volume/biopsy ratio were significant predictive parameters in gray-zone patients. The clinically insignificant cancer detection rate was significantly lower in the latter group compared with the former group (P=0.0008). CONCLUSION: The latter nomogram provided more acceptable detection rates of clinically significant and insignificant cancer than the former one, and we consider that an initial maximum 12-core transrectal ultrasound-guided needle biopsy may be sufficient for prostate cancer diagnosis. Dove Medical Press 2019-03-19 /pmc/articles/PMC6430996/ /pubmed/30937289 http://dx.doi.org/10.2147/RRU.S193933 Text en © 2019 Hori et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Hori, Shunta
Tanaka, Nobumichi
Nakai, Yasushi
Morizawa, Yosuke
Tatsumi, Yoshihiro
Miyake, Makito
Anai, Satoshi
Fujii, Tomomi
Konishi, Noboru
Nakagawa, Yoshinori
Hirao, Syuya
Fujimoto, Kiyohide
Comparison of cancer detection rates by transrectal prostate biopsy for prostate cancer using two different nomograms based on patient’s age and prostate volume
title Comparison of cancer detection rates by transrectal prostate biopsy for prostate cancer using two different nomograms based on patient’s age and prostate volume
title_full Comparison of cancer detection rates by transrectal prostate biopsy for prostate cancer using two different nomograms based on patient’s age and prostate volume
title_fullStr Comparison of cancer detection rates by transrectal prostate biopsy for prostate cancer using two different nomograms based on patient’s age and prostate volume
title_full_unstemmed Comparison of cancer detection rates by transrectal prostate biopsy for prostate cancer using two different nomograms based on patient’s age and prostate volume
title_short Comparison of cancer detection rates by transrectal prostate biopsy for prostate cancer using two different nomograms based on patient’s age and prostate volume
title_sort comparison of cancer detection rates by transrectal prostate biopsy for prostate cancer using two different nomograms based on patient’s age and prostate volume
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430996/
https://www.ncbi.nlm.nih.gov/pubmed/30937289
http://dx.doi.org/10.2147/RRU.S193933
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