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Spray drying OZ439 nanoparticles to form stable, water-dispersible powders for oral malaria therapy
BACKGROUND: OZ439 is a new chemical entity which is active against drug-resistant malaria and shows potential as a single-dose cure. However, development of an oral formulation with desired exposure has proved problematic, as OZ439 is poorly soluble (BCS Class II drug). In order to be feasible for l...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431012/ https://www.ncbi.nlm.nih.gov/pubmed/30902103 http://dx.doi.org/10.1186/s12967-019-1849-8 |