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Availability of benzathine penicillin G for syphilis treatment in Shandong Province, Eastern China

BACKGROUND: The shortage of benzathine penicillin G (BPG) worldwide presents a major challenge in the treatment of syphilis. Its availability for syphilis treatment has not been adequately evaluated in China. METHODS: Two surveys were conducted among hospitals providing sexually transmitted infectio...

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Autores principales: Chen, Xinlong, Li, Guigang, Gan, Yanling, Chu, Tongsheng, Liu, Dianchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431030/
https://www.ncbi.nlm.nih.gov/pubmed/30902053
http://dx.doi.org/10.1186/s12913-019-4006-4
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author Chen, Xinlong
Li, Guigang
Gan, Yanling
Chu, Tongsheng
Liu, Dianchang
author_facet Chen, Xinlong
Li, Guigang
Gan, Yanling
Chu, Tongsheng
Liu, Dianchang
author_sort Chen, Xinlong
collection PubMed
description BACKGROUND: The shortage of benzathine penicillin G (BPG) worldwide presents a major challenge in the treatment of syphilis. Its availability for syphilis treatment has not been adequately evaluated in China. METHODS: Two surveys were conducted among hospitals providing sexually transmitted infection clinical services in Shandong Province in 2012 and 2018. Data on the basic information and BPG availability of the surveyed hospitals and related factors were collected and analyzed using SPSS 17.0. RESULTS: A total of 433 and 515 hospitals were surveyed in 2012 and 2018, respectively. A significant difference in BPG availability was observed among different levels and types of hospitals both in 2012 (X(2) = 9.747, p = 0.008; X(2) = 37.167, p = 0.000) and 2018 (X(2) = 11.775, p = 0.003; X(2) = 28.331, p = 0.000). The BPG availability among surveyed hospitals increased from 45.0% in 2012 to 56.4% in 2018 (X(2) = 11.131, p = 0.001). The BPG availability was higher in 2018 than in 2012 among county-level hospitals (52.0% vs. 40.8%, X(2) = 7.783, p = 0.005), general western medicine hospitals (62.1% vs. 50.0%, X(2) = 6.742, p = 0.009), maternal and child health hospitals (57.1% vs. 26.9%, X(2) = 13.906, p = 0.000), and public hospitals (56.8% vs. 45.0%, X(2) = 11.361, p = 0.001). However, the county-level availability of BPG (at least one hospital has BPG in a county-level unit) has not improved between 2012 and 2018 (65.93% vs. 70.34%; X(2) = 0.563, p = 0.453). The absences of clinical needs, restriction of clinical antibacterial drugs, and lack of qualifications for providing syphilis treatment were the major reasons for the low BPG availability of hospitals. CONCLUSIONS: BPG availability for syphilis treatment in Shandong Province remains low and presents disparities among different levels and types of hospitals, although it has been improved in recent years. The low availability of BPG for syphilis treatment in China is related to its clinical use by doctors rather than the market supply. Health care reforms should further improve the availability and accessibility of health services. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12913-019-4006-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-64310302019-04-04 Availability of benzathine penicillin G for syphilis treatment in Shandong Province, Eastern China Chen, Xinlong Li, Guigang Gan, Yanling Chu, Tongsheng Liu, Dianchang BMC Health Serv Res Research Article BACKGROUND: The shortage of benzathine penicillin G (BPG) worldwide presents a major challenge in the treatment of syphilis. Its availability for syphilis treatment has not been adequately evaluated in China. METHODS: Two surveys were conducted among hospitals providing sexually transmitted infection clinical services in Shandong Province in 2012 and 2018. Data on the basic information and BPG availability of the surveyed hospitals and related factors were collected and analyzed using SPSS 17.0. RESULTS: A total of 433 and 515 hospitals were surveyed in 2012 and 2018, respectively. A significant difference in BPG availability was observed among different levels and types of hospitals both in 2012 (X(2) = 9.747, p = 0.008; X(2) = 37.167, p = 0.000) and 2018 (X(2) = 11.775, p = 0.003; X(2) = 28.331, p = 0.000). The BPG availability among surveyed hospitals increased from 45.0% in 2012 to 56.4% in 2018 (X(2) = 11.131, p = 0.001). The BPG availability was higher in 2018 than in 2012 among county-level hospitals (52.0% vs. 40.8%, X(2) = 7.783, p = 0.005), general western medicine hospitals (62.1% vs. 50.0%, X(2) = 6.742, p = 0.009), maternal and child health hospitals (57.1% vs. 26.9%, X(2) = 13.906, p = 0.000), and public hospitals (56.8% vs. 45.0%, X(2) = 11.361, p = 0.001). However, the county-level availability of BPG (at least one hospital has BPG in a county-level unit) has not improved between 2012 and 2018 (65.93% vs. 70.34%; X(2) = 0.563, p = 0.453). The absences of clinical needs, restriction of clinical antibacterial drugs, and lack of qualifications for providing syphilis treatment were the major reasons for the low BPG availability of hospitals. CONCLUSIONS: BPG availability for syphilis treatment in Shandong Province remains low and presents disparities among different levels and types of hospitals, although it has been improved in recent years. The low availability of BPG for syphilis treatment in China is related to its clinical use by doctors rather than the market supply. Health care reforms should further improve the availability and accessibility of health services. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12913-019-4006-4) contains supplementary material, which is available to authorized users. BioMed Central 2019-03-22 /pmc/articles/PMC6431030/ /pubmed/30902053 http://dx.doi.org/10.1186/s12913-019-4006-4 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Chen, Xinlong
Li, Guigang
Gan, Yanling
Chu, Tongsheng
Liu, Dianchang
Availability of benzathine penicillin G for syphilis treatment in Shandong Province, Eastern China
title Availability of benzathine penicillin G for syphilis treatment in Shandong Province, Eastern China
title_full Availability of benzathine penicillin G for syphilis treatment in Shandong Province, Eastern China
title_fullStr Availability of benzathine penicillin G for syphilis treatment in Shandong Province, Eastern China
title_full_unstemmed Availability of benzathine penicillin G for syphilis treatment in Shandong Province, Eastern China
title_short Availability of benzathine penicillin G for syphilis treatment in Shandong Province, Eastern China
title_sort availability of benzathine penicillin g for syphilis treatment in shandong province, eastern china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431030/
https://www.ncbi.nlm.nih.gov/pubmed/30902053
http://dx.doi.org/10.1186/s12913-019-4006-4
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