Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability

BACKGROUND: Epithelial-mesenchymal transition (EMT) may be one of the reasons for the failure in some clinical trials regarding histone deacetylase inhibitors (HDACIs)-treated solid tumors. We investigated the effects of a pan-HDACI trichostatin A (TSA) on the proliferation and EMT of nasopharyngeal...

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Detalles Bibliográficos
Autores principales: Shen, Zhihua, Liao, Xiaomin, Shao, Zhongming, Feng, Muyin, Yuan, Jianling, Wang, Sisi, Gan, Siyuan, Ha, Yanping, He, Zhiwei, Jie, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431036/
https://www.ncbi.nlm.nih.gov/pubmed/30902084
http://dx.doi.org/10.1186/s12885-019-5482-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431036/
https://www.ncbi.nlm.nih.gov/pubmed/30902084
http://dx.doi.org/10.1186/s12885-019-5482-y

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