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The past, present and future of anti-malarial medicines

Great progress has been made in recent years to reduce the high level of suffering caused by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria prevention and the use of artemisinin-based combination therapy (ACT) for malaria treatment have made a significant impact...

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Autores principales: Tse, Edwin G., Korsik, Marat, Todd, Matthew H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431062/
https://www.ncbi.nlm.nih.gov/pubmed/30902052
http://dx.doi.org/10.1186/s12936-019-2724-z
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author Tse, Edwin G.
Korsik, Marat
Todd, Matthew H.
author_facet Tse, Edwin G.
Korsik, Marat
Todd, Matthew H.
author_sort Tse, Edwin G.
collection PubMed
description Great progress has been made in recent years to reduce the high level of suffering caused by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria prevention and the use of artemisinin-based combination therapy (ACT) for malaria treatment have made a significant impact. Nevertheless, the development of resistance to the past and present anti-malarial drugs highlights the need for continued research to stay one step ahead. New drugs are needed, particularly those with new mechanisms of action. Here the range of anti-malarial medicines developed over the years are reviewed, beginning with the discovery of quinine in the early 1800s, through to modern day ACT and the recently-approved tafenoquine. A number of new potential anti-malarial drugs currently in development are outlined, along with a description of the hit to lead campaign from which it originated. Finally, promising novel mechanisms of action for these and future anti-malarial medicines are outlined. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12936-019-2724-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-64310622019-04-04 The past, present and future of anti-malarial medicines Tse, Edwin G. Korsik, Marat Todd, Matthew H. Malar J Review Great progress has been made in recent years to reduce the high level of suffering caused by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria prevention and the use of artemisinin-based combination therapy (ACT) for malaria treatment have made a significant impact. Nevertheless, the development of resistance to the past and present anti-malarial drugs highlights the need for continued research to stay one step ahead. New drugs are needed, particularly those with new mechanisms of action. Here the range of anti-malarial medicines developed over the years are reviewed, beginning with the discovery of quinine in the early 1800s, through to modern day ACT and the recently-approved tafenoquine. A number of new potential anti-malarial drugs currently in development are outlined, along with a description of the hit to lead campaign from which it originated. Finally, promising novel mechanisms of action for these and future anti-malarial medicines are outlined. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12936-019-2724-z) contains supplementary material, which is available to authorized users. BioMed Central 2019-03-22 /pmc/articles/PMC6431062/ /pubmed/30902052 http://dx.doi.org/10.1186/s12936-019-2724-z Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Tse, Edwin G.
Korsik, Marat
Todd, Matthew H.
The past, present and future of anti-malarial medicines
title The past, present and future of anti-malarial medicines
title_full The past, present and future of anti-malarial medicines
title_fullStr The past, present and future of anti-malarial medicines
title_full_unstemmed The past, present and future of anti-malarial medicines
title_short The past, present and future of anti-malarial medicines
title_sort past, present and future of anti-malarial medicines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431062/
https://www.ncbi.nlm.nih.gov/pubmed/30902052
http://dx.doi.org/10.1186/s12936-019-2724-z
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