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Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia

AIM OF THE STUDY: Biliary atresia (BA) is an uncommon disorder of the liver and bile ducts affecting infants and is characterized by progressive fibrosclerosing obstruction of the extrahepatic biliary tree leading to end-stage liver failure. The purpose of this study was to determine serum glypican-...

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Autores principales: Sirisomboonlarp, Kanjaporn, Udomsinprasert, Wanvisa, McConachie, Ellie, Woraruthai, Thamonwan, Poovorawan, Yong, Honsawek, Sittisak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431085/
https://www.ncbi.nlm.nih.gov/pubmed/30915406
http://dx.doi.org/10.5114/ceh.2019.83156
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author Sirisomboonlarp, Kanjaporn
Udomsinprasert, Wanvisa
McConachie, Ellie
Woraruthai, Thamonwan
Poovorawan, Yong
Honsawek, Sittisak
author_facet Sirisomboonlarp, Kanjaporn
Udomsinprasert, Wanvisa
McConachie, Ellie
Woraruthai, Thamonwan
Poovorawan, Yong
Honsawek, Sittisak
author_sort Sirisomboonlarp, Kanjaporn
collection PubMed
description AIM OF THE STUDY: Biliary atresia (BA) is an uncommon disorder of the liver and bile ducts affecting infants and is characterized by progressive fibrosclerosing obstruction of the extrahepatic biliary tree leading to end-stage liver failure. The purpose of this study was to determine serum glypican-3 (GPC3) levels and liver stiffness in children with BA and the correlation of glypican-3 with clinical parameters. MATERIAL AND METHODS: Seventy-five post-Kasai BA patients and 28 healthy age-matched controls were registered. Serum GPC3 levels were examined by enzyme-linked immunosorbent assay. Liver stiffness measurement was analyzed by transient elastography. RESULTS: BA patients had significantly greater serum GPC3 and liver stiffness values than controls (p < 0.001). Serum GPC3 and liver stiffness values were significantly higher in jaundiced BA patients than in non-jaundiced BA patients (p < 0.001). Additionally, serum glypican-3 was associated with liver stiffness and serum total bilirubin (p < 0.001, respectively). CONCLUSIONS: Elevated serum GPC3 levels were associated with hepatic dysfunction and the severity of BA. As a result, serum GPC3 and liver stiffness might serve as biomarkers reflecting the deterioration of hepatic function and the outcome in post-Kasai BA.
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spelling pubmed-64310852019-03-26 Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia Sirisomboonlarp, Kanjaporn Udomsinprasert, Wanvisa McConachie, Ellie Woraruthai, Thamonwan Poovorawan, Yong Honsawek, Sittisak Clin Exp Hepatol Original Paper AIM OF THE STUDY: Biliary atresia (BA) is an uncommon disorder of the liver and bile ducts affecting infants and is characterized by progressive fibrosclerosing obstruction of the extrahepatic biliary tree leading to end-stage liver failure. The purpose of this study was to determine serum glypican-3 (GPC3) levels and liver stiffness in children with BA and the correlation of glypican-3 with clinical parameters. MATERIAL AND METHODS: Seventy-five post-Kasai BA patients and 28 healthy age-matched controls were registered. Serum GPC3 levels were examined by enzyme-linked immunosorbent assay. Liver stiffness measurement was analyzed by transient elastography. RESULTS: BA patients had significantly greater serum GPC3 and liver stiffness values than controls (p < 0.001). Serum GPC3 and liver stiffness values were significantly higher in jaundiced BA patients than in non-jaundiced BA patients (p < 0.001). Additionally, serum glypican-3 was associated with liver stiffness and serum total bilirubin (p < 0.001, respectively). CONCLUSIONS: Elevated serum GPC3 levels were associated with hepatic dysfunction and the severity of BA. As a result, serum GPC3 and liver stiffness might serve as biomarkers reflecting the deterioration of hepatic function and the outcome in post-Kasai BA. Termedia Publishing House 2019-02-20 2019-03 /pmc/articles/PMC6431085/ /pubmed/30915406 http://dx.doi.org/10.5114/ceh.2019.83156 Text en Copyright: © 2019 Clinical and Experimental Hepatology http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Sirisomboonlarp, Kanjaporn
Udomsinprasert, Wanvisa
McConachie, Ellie
Woraruthai, Thamonwan
Poovorawan, Yong
Honsawek, Sittisak
Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia
title Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia
title_full Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia
title_fullStr Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia
title_full_unstemmed Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia
title_short Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia
title_sort increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431085/
https://www.ncbi.nlm.nih.gov/pubmed/30915406
http://dx.doi.org/10.5114/ceh.2019.83156
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